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1422-07-7 Usage


CODEINE HYDROCHLORIDE is an opioid receptor agonist that serves as an analgesic. It is a white or almost white, crystalline powder or small, colourless crystals. CODEINE HYDROCHLORIDE is used for its pain-relieving properties and is commonly prescribed to manage mild to moderate pain.


Used in Pharmaceutical Industry:
CODEINE HYDROCHLORIDE is used as an analgesic for the treatment of mild to moderate pain. It works by binding to the opioid receptors in the brain, providing relief from pain and a sense of well-being.
Used in Medical Applications:
CODEINE HYDROCHLORIDE is also used in various medical applications, such as cough suppressants and antidiarrheal medications, due to its ability to reduce the cough reflex and slow down intestinal motility, respectively.

Contact allergens

Codeine has been reported as an occupational sensitizer in workers in the production of opium alkaloids. Codeine has been responsible for fixed drug eruptions or generalized dermatitis. Cross-sensitivity is expected to morphine.

Check Digit Verification of cas no

The CAS Registry Mumber 1422-07-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,2 and 2 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1422-07:
47 % 10 = 7
So 1422-07-7 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017


1.1 GHS Product identifier


1.2 Other means of identification

Product number -
Other names Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, hydrochloride, (5α,6α)-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1422-07-7 SDS

1422-07-7Upstream product

1422-07-7Relevant articles and documents

Efficient iron-catalyzed n-demethylation of tertiary amine-N-oxides under oxidative conditions

Kok, Gaik B.,Scammells, Peter J.

experimental part, p. 1515 - 1521 (2012/02/04)

An investigation into the influence of oxidative conditions on the efficiency of opiate N-demethylation using iron powder has been carried out under non-classical Polonovski conditions. This approach involves a two-step process of N-oxidation and subsequent treatment of the intermediate N-oxide hydrochloride with the redox catalyst. Significant improvements in rate and yield have been realized for these reactions in the presence of molecular oxygen. In this context, further rate enhancement was achieved by the judicious addition of small amounts of ferric ions, leading to a concomitant reduction in the amount of the zero-valent iron primary catalyst that is required. This has led to a generalized improved methodology for the N-demethylation of oripavine, codeine, morphine, and thebaine. This protocol can also be carried out in one-pot without the need to isolate the intermediate N-oxide.