(6S)-5-[(E)-ethylidene]-6-methyl-6-{[(1R)-1-phenylethyl]amino}-tetrahydro-2H-2-pyranone

Base Information

Chemical Name:(6S)-5-[(E)-ethylidene]-6-methyl-6-{[(1R)-1-phenylethyl]amino}-tetrahydro-2H-2-pyranone
CAS No.:202188-76-9
Molecular Formula:C₁₆H₂₁NO₂
Molecular Weight:259.348
Hs Code.:

Synonyms:(6S)-5-[(E)-ethylidene]-6-methyl-6-{[(1R)-1-phenylethyl]amino}-tetrahydro-2H-2-pyranone

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Chemical Property of (6S)-5-[(E)-ethylidene]-6-methyl-6-{[(1R)-1-phenylethyl]amino}-tetrahydro-2H-2-pyranone

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Technology Process of (6S)-5-[(E)-ethylidene]-6-methyl-6-{[(1R)-1-phenylethyl]amino}-tetrahydro-2H-2-pyranone

There total 3 articles about (6S)-5-[(E)-ethylidene]-6-methyl-6-{[(1R)-1-phenylethyl]amino}-tetrahydro-2H-2-pyranone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 202188-69-0
5-(1-hydroxyethyl)-6-methyl-1-[(1R)-1-phenylethyl]-1,2,3,4-tetrahydro-2-pyridinone

: 202188-76-9
(6S)-5-[(E)-ethylidene]-6-methyl-6-{[(1R)-1-phenylethyl]amino}-tetrahydro-2H-2-pyranone

Guidance literature:: In acetic acid; at 40 ℃; for 1h;
DOI:10.1016/S0040-4020(97)10333-7

Reference yield:

: 4-N<(R)-1-Phenylethyl>-amino-3-penten-2-on

: 202188-76-9
(6S)-5-[(E)-ethylidene]-6-methyl-6-{[(1R)-1-phenylethyl]amino}-tetrahydro-2H-2-pyranone

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / Heating

2: 95 percent / NaBH₄ / methanol / 0 °C

3: 72 percent / acetic acid / 1 h / 40 °C

With sodium tetrahydroborate; In tetrahydrofuran; methanol; acetic acid; 1: Cyclization / 2: Reduction / 3: Isomerization;
DOI:10.1016/S0040-4020(97)10333-7

Reference yield:

: 202188-57-6
5-acetyl-6-methyl-1-[(1R)-1-phenylethyl]-1,2,3,4-tetrahydro-2-pyridinone

: 202188-76-9
(6S)-5-[(E)-ethylidene]-6-methyl-6-{[(1R)-1-phenylethyl]amino}-tetrahydro-2H-2-pyranone

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / NaBH₄ / methanol / 0 °C

2: 72 percent / acetic acid / 1 h / 40 °C

With sodium tetrahydroborate; In methanol; acetic acid; 1: Reduction / 2: Isomerization;
DOI:10.1016/S0040-4020(97)10333-7