5-acetyl-6-methyl-1-[(1R)-1-phenylethyl]-1,2,3,4-tetrahydro-2-pyridinone

Base Information

• Chemical Name: 5-acetyl-6-methyl-1-[(1R)-1-phenylethyl]-1,2,3,4-tetrahydro-2-pyridinone
• CAS No.: 202188-57-6
• Molecular Formula: C₁₆H₁₉NO₂
• Molecular Weight: 257.332
• Mol file: 202188-57-6.mol

Synonyms:5-acetyl-6-methyl-1-[(1R)-1-phenylethyl]-1,2,3,4-tetrahydro-2-pyridinone

Chemical Property of 5-acetyl-6-methyl-1-[(1R)-1-phenylethyl]-1,2,3,4-tetrahydro-2-pyridinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-acetyl-6-methyl-1-[(1R)-1-phenylethyl]-1,2,3,4-tetrahydro-2-pyridinone

There total 1 articles about 5-acetyl-6-methyl-1-[(1R)-1-phenylethyl]-1,2,3,4-tetrahydro-2-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acryloyl chloride (814-68-6,25189-84-8) + 4-N<(R)-1-Phenylethyl>-amino-3-penten-2-on → 5-acetyl-6-methyl-1-[(1R)-1-phenylethyl]-1,2,3,4-tetrahydro-2-pyridinone (202188-57-6)

Guidance literature:

In tetrahydrofuran; Heating;

DOI:10.1016/S0040-4020(97)10333-7

Reference yield: 95.0%

5-acetyl-6-methyl-1-[(1R)-1-phenylethyl]-1,2,3,4-tetrahydro-2-pyridinone (202188-57-6) → 5-(1-hydroxyethyl)-6-methyl-1-[(1R)-1-phenylethyl]-1,2,3,4-tetrahydro-2-pyridinone (202188-69-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃;

DOI:10.1016/S0040-4020(97)10333-7

Reference yield:

5-acetyl-6-methyl-1-[(1R)-1-phenylethyl]-1,2,3,4-tetrahydro-2-pyridinone (202188-57-6) → 5-ethyl-6-methyl-6-{[(1R)-1-phenylethyl]amino}tetrahydro-2H-2-pyranone

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / NaBH₄ / methanol / 0 °C

2: 72 percent / acetic acid / 1 h / 40 °C

3: 93 percent / hydrogen / Pd(OH)2/C / ethanol / 15 h / 20 °C / 3620.04 Torr

With sodium tetrahydroborate; hydrogen; palladium dihydroxide; In methanol; ethanol; acetic acid; 1: Reduction / 2: Isomerization / 3: Catalytic hydrogenation;

DOI:10.1016/S0040-4020(97)10333-7

upstream raw materials:

acryloyl chloride

Downstream raw materials:

5-(1-hydroxyethyl)-6-methyl-1-[(1R)-1-phenylethyl]-1,2,3,4-tetrahydro-2-pyridinone

(6S)-5-[(E)-ethylidene]-6-methyl-6-{[(1R)-1-phenylethyl]amino}-tetrahydro-2H-2-pyranone