2-[1-(3,5-Dichloro-phenyl)-meth-(E)-ylidene]-4-p-tolyl-but-3-ynoic acid

Base Information

• Chemical Name: 2-[1-(3,5-Dichloro-phenyl)-meth-(E)-ylidene]-4-p-tolyl-but-3-ynoic acid
• CAS No.: 201413-06-1
• Molecular Formula: C₁₈H₁₂Cl₂O₂
• Molecular Weight: 331.198
• Mol file: 201413-06-1.mol

Synonyms:2-[1-(3,5-Dichloro-phenyl)-meth-(E)-ylidene]-4-p-tolyl-but-3-ynoic acid

Chemical Property of 2-[1-(3,5-Dichloro-phenyl)-meth-(E)-ylidene]-4-p-tolyl-but-3-ynoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[1-(3,5-Dichloro-phenyl)-meth-(E)-ylidene]-4-p-tolyl-but-3-ynoic acid

There total 3 articles about 2-[1-(3,5-Dichloro-phenyl)-meth-(E)-ylidene]-4-p-tolyl-but-3-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dichlorophenylmagnesium bromide (82297-90-3) → 2-[1-(3,5-Dichloro-phenyl)-meth-(E)-ylidene]-4-p-tolyl-but-3-ynoic acid (201413-06-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) ZnCl₂ / 2) Pd(PPh₃)4 / 1) THF, room temperature, 0.5 h, 2) THF, 20 deg C, 24 h

2: 1) ZnCl₂ / 2) Pd(PPh₃)4 / 1) THF, 2) THF, 20 deg C, 1.5 h; 70 deg C, 6 h

3: KOH / tetrahydrofuran; H₂O / 18 h / Ambient temperature

With potassium hydroxide; zinc(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water;

DOI:10.1016/S0040-4020(97)10265-4

Reference yield:

(Z)-2-Bromo-3-(3,5-dichloro-phenyl)-acrylic acid methyl ester (201412-94-4) → 2-[1-(3,5-Dichloro-phenyl)-meth-(E)-ylidene]-4-p-tolyl-but-3-ynoic acid (201413-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) ZnCl₂ / 2) Pd(PPh₃)4 / 1) THF, 2) THF, 20 deg C, 1.5 h; 70 deg C, 6 h

2: KOH / tetrahydrofuran; H₂O / 18 h / Ambient temperature

With potassium hydroxide; zinc(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water;

DOI:10.1016/S0040-4020(97)10265-4

Reference yield:

2-[1-(3,5-Dichloro-phenyl)-meth-(E)-ylidene]-4-p-tolyl-but-3-ynoic acid methyl ester (201412-98-8) → 2-[1-(3,5-Dichloro-phenyl)-meth-(E)-ylidene]-4-p-tolyl-but-3-ynoic acid (201413-06-1)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; water; for 18h; Ambient temperature;

DOI:10.1016/S0040-4020(97)10265-4

upstream raw materials:

2-[1-(3,5-Dichloro-phenyl)-meth-(E)-ylidene]-4-p-tolyl-but-3-ynoic acid methyl ester

3,5-dichlorophenylmagnesium bromide

(Z)-2-Bromo-3-(3,5-dichloro-phenyl)-acrylic acid methyl ester