Dodecanoic acid (2R,3R,4R,5R)-4-dodecanoyloxy-5-methoxy-2-trityloxymethyl-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: Dodecanoic acid (2R,3R,4R,5R)-4-dodecanoyloxy-5-methoxy-2-trityloxymethyl-tetrahydro-furan-3-yl ester
• CAS No.: 300583-27-1
• Molecular Formula: C₄₉H₇₀O₇
• Molecular Weight: 771.091
• Mol file: 300583-27-1.mol

Synonyms:Dodecanoic acid (2R,3R,4R,5R)-4-dodecanoyloxy-5-methoxy-2-trityloxymethyl-tetrahydro-furan-3-yl ester

Chemical Property of Dodecanoic acid (2R,3R,4R,5R)-4-dodecanoyloxy-5-methoxy-2-trityloxymethyl-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Dodecanoic acid (2R,3R,4R,5R)-4-dodecanoyloxy-5-methoxy-2-trityloxymethyl-tetrahydro-furan-3-yl ester

There total 4 articles about Dodecanoic acid (2R,3R,4R,5R)-4-dodecanoyloxy-5-methoxy-2-trityloxymethyl-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

lauric acid (143-07-7) + (-)-Methyl-5-O-trityl-β-D-ribofuranosid (50908-04-8) → Dodecanoic acid (2R,3R,4R,5R)-4-dodecanoyloxy-5-methoxy-2-trityloxymethyl-tetrahydro-furan-3-yl ester (300583-27-1)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 40 ℃; for 48h;

DOI:10.1016/S0009-3084(02)00073-7

Reference yield:

1-O-methyl-D-ribofuranose (7473-45-2) → Dodecanoic acid (2R,3R,4R,5R)-4-dodecanoyloxy-5-methoxy-2-trityloxymethyl-tetrahydro-furan-3-yl ester (300583-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / pyridine / 3 h / 120 °C

2: DMAP; DCC / dimethylformamide / 48 h / 40 °C

With pyridine; dmap; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1016/S0009-3084(02)00073-7

Reference yield:

trityl chloride (76-83-5) → Dodecanoic acid (2R,3R,4R,5R)-4-dodecanoyloxy-5-methoxy-2-trityloxymethyl-tetrahydro-furan-3-yl ester (300583-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / pyridine / 3 h / 120 °C

2: DMAP; DCC / dimethylformamide / 48 h / 40 °C

With pyridine; dmap; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1016/S0009-3084(02)00073-7

upstream raw materials:

lauric acid

(-)-Methyl-5-O-trityl-β-D-ribofuranosid

trityl chloride

1-O-methyl-D-ribofuranose