(S)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)propionic acid methyl ester

Base Information

Chemical Name:(S)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)propionic acid methyl ester
CAS No.:353242-39-4
Molecular Formula:C₁₃H₁₆N₂O₆
Molecular Weight:296.28
Hs Code.:

Synonyms:(S)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)propionic acid methyl ester

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Chemical Property of (S)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)propionic acid methyl ester

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Technology Process of (S)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)propionic acid methyl ester

There total 6 articles about (S)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 353242-37-2
(Z)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)acrylic acid methyl ester

: 353242-39-4
(S)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)propionic acid methyl ester

Guidance literature:: With hydrogen; Rh⁺[L₁^*][COD]SbF₆^-; In tetrahydrofuran; under 2327.23 Torr;
DOI:10.1021/ol016018b

Reference yield:

: 96-96-8
4-methoxy-2-nitroaniline

: 353242-39-4
(S)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: c. hydrochloric acid / H₂O / 0.33 h / Heating

1.2: sodium nitrite / H₂O / 0.5 h

1.3: 78 percent / copper cyanide / H₂O / 2 h / Heating

2.1: DIBAL / toluene; diethyl ether / 0.33 h / 0 °C

2.2: 99 percent / silica gel / toluene; diethyl ether

3.1: DBU / CH₂Cl₂ / 0.17 h

3.2: CH₂Cl₂ / 2 h / 20 °C

4.1: 98 percent / H₂ / Rh⁺[L₁^*][COD]SbF₆^- / tetrahydrofuran / 2327.23 Torr

With hydrogenchloride; hydrogen; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; Rh⁺[L₁^*][COD]SbF₆^-; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene; 3.1: Wadsworth-Emmons reaction;
DOI:10.1021/ol016018b

Reference yield:

: 35356-70-8
Methyl 2-acetamidoacrylate

: 353242-39-4
(S)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammonium chloride hydrate; sodium bicarbonate / palladium acetate / 24 h / 80 °C

2: 98 percent / H₂ / Rh⁺[L₁^*][COD]SbF₆^- / tetrahydrofuran / 2327.23 Torr

With tetrabutyl-ammonium chloride; hydrogen; sodium hydrogencarbonate; Rh⁺[L₁^*][COD]SbF₆^-; palladium diacetate; In tetrahydrofuran; 1: Heck reaction;
DOI:10.1021/ol016018b