353242-37-2

Basic information

• Product Name: (Z)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)acrylic acid methyl ester
• Synonyms: (Z)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)acrylic acid methyl ester
• CAS NO: 353242-37-2
• Molecular Weight: 294.264
• Mol File: 353242-37-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)acrylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)acrylic acid methyl ester(353242-37-2)
• EPA Substance Registry System: (Z)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)acrylic acid methyl ester(353242-37-2)

Safety Data

• Hazardous Substances Data: 353242-37-2(Hazardous Substances Data)

Upstream product

• 96-96-8 4-methoxy-2-nitroaniline 
• 22996-21-0 4-methoxy-2-nitro-benzaldehyde 
• 38469-83-9 4-methoxy-2-nitro-benzonitrile 

Downstream Products

• 353242-45-2 (S)-3-acetamido-7-methoxy-1-(4-toluenesulfonyl)-1,2,3,4-tetrahydro-quinoline 
• 353242-43-0 (S)-N-(1-methanesulfonyloxymethyl-2-(4-methoxy-2-nitrophenyl)-ethyl)-acetamide 
• 353242-42-9 (S)-N-(1-hydroxymethyl-2-(4-methoxy-2-nitrophenyl)-ethyl)-acetamide 
• 353242-39-4 (S)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)propionic acid methyl ester 

Relevant articles and documents

Asymmetric Synthesis of Functionalized 1,2,3,4-Tetrahydroquinolines

Highly enantioselective rhodium-catalyzed asymmetric hydrogenation (>98% ee) and Sharpless epoxidation (>90% ee) of o-nitrocinnamyl substrates lead to intermediates that can be transformed into tetrahydroquinoline derivatives. Starting materials are produced in high-yielding Heck reactions of an o-nitroaryl iodide and α-acetamidoacrylate or methyl acrylate.