(R,S)-N-benzyl-2-acetamido-6-(benzyloxycarbonyl)aminohexanamide

Base Information

• Chemical Name: (R,S)-N-benzyl-2-acetamido-6-(benzyloxycarbonyl)aminohexanamide
• CAS No.: 168843-67-2
• Molecular Formula: C₂₃H₂₉N₃O₄
• Molecular Weight: 411.501
• Mol file: 168843-67-2.mol

Synonyms:(R,S)-N-benzyl-2-acetamido-6-(benzyloxycarbonyl)aminohexanamide

Chemical Property of (R,S)-N-benzyl-2-acetamido-6-(benzyloxycarbonyl)aminohexanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,S)-N-benzyl-2-acetamido-6-(benzyloxycarbonyl)aminohexanamide

There total 2 articles about (R,S)-N-benzyl-2-acetamido-6-(benzyloxycarbonyl)aminohexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(R,S)-2-acetamido-6-N-(benzyloxycarbonyl)aminohexanoic acid (32302-84-4) + benzylamine (100-46-9) → (R,S)-N-benzyl-2-acetamido-6-(benzyloxycarbonyl)aminohexanamide (168843-67-2)

Guidance literature:

(R,S)-2-acetamido-6-N-(benzyloxycarbonyl)aminohexanoic acid; With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 5 ℃;

benzylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1021/jm020225f

Reference yield:

N-ε-benzyloxycarbonyl lysine (32302-83-3,57705-97-2,67178-46-5,25931-47-9) → (R,S)-N-benzyl-2-acetamido-6-(benzyloxycarbonyl)aminohexanamide (168843-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 99 percent / triethylamine / aq. NaOH / 2 h / 0 - 20 °C

2.1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide; 1-hydroxybenzotriazole; 4-methylmorpholine / dimethylformamide / 5 °C

2.2: 89 percent / dimethylformamide / 12 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In sodium hydroxide; N,N-dimethyl-formamide;

DOI:10.1021/jm020225f

Reference yield: 99.0%

(R,S)-N-benzyl-2-acetamido-6-(benzyloxycarbonyl)aminohexanamide (168843-67-2) → (R,S)-N-benzyl-2-acetamido-6-aminohexanamide (168843-71-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr;

DOI:10.1021/jm020225f

upstream raw materials:

(R,S)-2-acetamido-6-N-(benzyloxycarbonyl)aminohexanoic acid

benzylamine

N-ε-benzyloxycarbonyl lysine

Downstream raw materials:

(R,S)-N-benzyl-2-acetamido-6-aminohexanamide