4-Fluoro-alpha-methylstyrene

Base Information

• Chemical Name: 4-Fluoro-alpha-methylstyrene
• CAS No.: 14584-33-9
• Molecular Formula: C9H9 F
• Molecular Weight: 136.169
• Hs Code.: 2903999090
• Mol file: 14584-33-9.mol

Synonyms:Styrene, a-(fluoromethyl)- (8CI)

Chemical Property of 4-Fluoro-alpha-methylstyrene

Chemical Property:

• PSA: 0.00000
• LogP: 2.85880

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluoro-alpha-methylstyrene

There total 14 articles about 4-Fluoro-alpha-methylstyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-phenylallyltrimethylsilane (77130-15-5) → 2,2,2-trifluoro-1-phenylethan-1-one (14584-33-9)

Guidance literature:

With Selectfluor; In acetonitrile; at 22 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jacs.0c10899

Reference yield: 67.0%

3-hydroxy-2-phenylpropene (6006-81-1) → 2,2,2-trifluoro-1-phenylethan-1-one (14584-33-9)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1055/s-0029-1218785

Reference yield: 66.0%

2-phenylprop-2-en-1-yl 4-nitrobenzoate (1286796-32-4) → 2,2,2-trifluoro-1-phenylethan-1-one (14584-33-9)

Guidance literature:

With tetrabutyl ammonium fluoride; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tert-butyl alcohol; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201007307

upstream raw materials:

isopropenylbenzene

1-phenyl-1-trimethylsiloxycyclopropane

acetonitrile

2-phenylallyltrimethylsilane

Refernces

• 1、 Kirihara, Masayuki,Kambayashi, Toshihiro,Momose, Takefumi. "Allylic fluorides via the cleavage of tertiary cyclopropyl silyl ethers with diethylaminosulfur trifluoride". . p. 1103 - 1104. Retrieved 1996.
• 2、 Stavber, Stojan,Pecan, Tjasa Sotler,Papez, Maja,Zupan, Marko. "Ritter-type fluorofunctionalisation as a new, effective method for conversion of alkenes to vicinal fluoroamides". . p. 2247 - 2248. Retrieved 1996.
• 3、 Lu, Lingxiang,Siu, Juno C.,Lai, Yihuan,Lin, Song. "An Electroreductive Approach to Radical Silylation via the Activation of Strong Si-Cl Bond". supporting information. p. 21272 - 21278. Retrieved 2020/12/21.
• 4、 Bloom, Steven,Pitts, Cody Ross,Miller, David Curtin,Haselton, Nathan,Holl, Maxwell Gargiulo,Urheim, Ellen,Lectka, Thomas. "A polycomponent metal-catalyzed aliphatic, allylic, and benzylic fluorination". . p. 10580 - 10583,4. Retrieved 2020/09/02.