(3S)-3-methyl-3-[(1R)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(3S)-3-methyl-3-[(1R)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester
CAS No.:1351667-91-8
Molecular Formula:C₂₂H₂₄N₂O₅
Molecular Weight:396.443
Hs Code.:

Synonyms:(3S)-3-methyl-3-[(1R)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

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Chemical Property of (3S)-3-methyl-3-[(1R)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

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Technology Process of (3S)-3-methyl-3-[(1R)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

There total 12 articles about (3S)-3-methyl-3-[(1R)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 102-96-5
(2-nitroethenyl)benzene

: 214610-11-4
tert-butyl 3-methyl-2-oxoindoline-1-carboxylate

: 1168139-70-5
(3R)-3-methyl-3-[(1S)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

: 1351667-91-8
(3S)-3-methyl-3-[(1R)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: With 1-((1S,2S)-2-(dimethylamino)cyclohexyl)-3-(2,2,2-trifluoroethyl)thiourea; In dichloromethane; at -40 ℃; for 72h; optical yield given as %ee; stereoselective reaction;
DOI:10.1002/adsc.200900630

Reference yield:

: 102-96-5
(2-nitroethenyl)benzene

: 214610-11-4
tert-butyl 3-methyl-2-oxoindoline-1-carboxylate

: 1168139-70-5
(3R)-3-methyl-3-[(1S)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

: 1245563-62-5
tert-butyl 3-methyl-3-[2-nitro-1-phenylethyl]-2-oxoindoline-1-carboxylate

: 1351667-91-8
(3S)-3-methyl-3-[(1R)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: With Bis-HQN-SQA; In dichloromethane; at -20 ℃; for 12h; optical yield given as %ee; enantioselective reaction;
DOI:10.1016/j.tetasy.2012.06.018

Reference yield:

: 102-96-5
(2-nitroethenyl)benzene

: 214610-11-4
tert-butyl 3-methyl-2-oxoindoline-1-carboxylate

: 1168139-70-5
(3R)-3-methyl-3-[(1S)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

: 1351667-91-8
(3S)-3-methyl-3-[(1R)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

: 3-methyl-3-[2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: With C₃₄H₂₀N₂Ni₂O₄; In ethyl acetate; at 20 - 25 ℃; for 33h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ja903566u