tert-butyl-3-methyl-3-(2-nitro-1-phenylethyl)-2-oxoindoline-1-carboxylate

Base Information

Chemical Name:tert-butyl-3-methyl-3-(2-nitro-1-phenylethyl)-2-oxoindoline-1-carboxylate
CAS No.:1245563-62-5
Molecular Formula:C₂₂H₂₄N₂O₅
Molecular Weight:396.443
Hs Code.:

Synonyms:tert-butyl-3-methyl-3-(2-nitro-1-phenylethyl)-2-oxoindoline-1-carboxylate

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Chemical Property of tert-butyl-3-methyl-3-(2-nitro-1-phenylethyl)-2-oxoindoline-1-carboxylate

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Technology Process of tert-butyl-3-methyl-3-(2-nitro-1-phenylethyl)-2-oxoindoline-1-carboxylate

There total 6 articles about tert-butyl-3-methyl-3-(2-nitro-1-phenylethyl)-2-oxoindoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 5153-67-3
nitrostyrene

: 214610-11-4
tert-butyl 3-methyl-2-oxoindoline-1-carboxylate

: 1245563-62-5
tert-butyl-3-methyl-3-(2-nitro-1-phenylethyl)-2-oxoindoline-1-carboxylate

Guidance literature:: With C₄₈H₅₂Cl₂N₆NiO₂Pd; In dichloromethane; at 20 ℃; for 20h; Reagent/catalyst; Optical yield = 66 %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/om3008629

Reference yield:

: 102-96-5
(2-nitroethenyl)benzene

: 214610-11-4
tert-butyl 3-methyl-2-oxoindoline-1-carboxylate

: 1168139-70-5
(3R)-3-methyl-3-[(1S)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

: 1245563-62-5
tert-butyl 3-methyl-3-[2-nitro-1-phenylethyl]-2-oxoindoline-1-carboxylate

: 1351667-91-8
(3S)-3-methyl-3-[(1R)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

Guidance literature:: With Bis-HQN-SQA; In dichloromethane; at -20 ℃; for 12h; optical yield given as %ee; enantioselective reaction;
DOI:10.1016/j.tetasy.2012.06.018

Reference yield:

: 5153-67-3
nitrostyrene

: 214610-11-4
tert-butyl 3-methyl-2-oxoindoline-1-carboxylate

: 1168139-70-5
(3R)-3-methyl-3-[(1S)-2-nitro-1-phenyl-ethyl]-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

: 1245563-62-5
tert-butyl 3-methyl-3-[2-nitro-1-phenylethyl]-2-oxoindoline-1-carboxylate

Guidance literature:: With 1-((1R,2R)-2-(bis(3-phenylpropyl)amino)cyclohexyl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea; In chloroform; at -20 ℃; for 24h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ja903520c