tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate
CAS No.:1207455-08-0
Molecular Formula:C₃₃H₃₆FN₅O₃
Molecular Weight:569.679
Hs Code.:

Synonyms:tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate

There total 11 articles about tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1207454-44-1
4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzaldehyde

: 120737-78-2
tert-butyl 2-methylpiperazine-1-carboxylate

: 1207455-08-0
tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate

Guidance literature:: 4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzaldehyde; tert-butyl 2-methylpiperazine-1-carboxylate; In dichloromethane; at 20 ℃;

With sodium cyanoborohydride; In dichloromethane; for 5h;

Reference yield:

: 641-70-3
3-nitrophthalic acid anhydride

: 1207455-08-0
tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 °C

1.2: pH 1

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

3.1: magnesium sulfate / dichloromethane / Reflux

4.1: 20 °C

5.1: hydrazine hydrate / 20 °C

5.2: 1 h / 0 - 20 °C

6.1: dichloromethane / 20 °C

6.2: 5 h

With sodium tetrahydroborate; hydrogen; magnesium sulfate; hydrazine hydrate; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

: 65399-18-0
4-nitrophthalide

: 1207455-08-0
tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

2.1: magnesium sulfate / dichloromethane / Reflux

3.1: 20 °C

4.1: hydrazine hydrate / 20 °C

4.2: 1 h / 0 - 20 °C

5.1: dichloromethane / 20 °C

5.2: 5 h

With hydrogen; magnesium sulfate; hydrazine hydrate; palladium 10% on activated carbon; In dichloromethane; ethyl acetate;