tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate
• CAS No.: 1207455-08-0
• Molecular Formula: C₃₃H₃₆FN₅O₃
• Molecular Weight: 569.679
• Mol file: 1207455-08-0.mol

Synonyms:tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate

Chemical Property of tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate

There total 11 articles about tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzaldehyde (1207454-44-1) + tert-butyl 2-methylpiperazine-1-carboxylate (120737-78-2) → tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate (1207455-08-0)

Guidance literature:

4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzaldehyde; tert-butyl 2-methylpiperazine-1-carboxylate; In dichloromethane; at 20 ℃;

With sodium cyanoborohydride; In dichloromethane; for 5h;

Reference yield:

3-nitrophthalic acid anhydride (641-70-3) → tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate (1207455-08-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 3 h / 0 °C

1.2: pH 1

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

3.1: magnesium sulfate / dichloromethane / Reflux

4.1: 20 °C

5.1: hydrazine hydrate / 20 °C

5.2: 1 h / 0 - 20 °C

6.1: dichloromethane / 20 °C

6.2: 5 h

With sodium tetrahydroborate; hydrogen; magnesium sulfate; hydrazine hydrate; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

4-nitrophthalide (65399-18-0) → tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2-methylpiperazine-1-carboxylate (1207455-08-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 25 °C / 760.05 Torr

2.1: magnesium sulfate / dichloromethane / Reflux

3.1: 20 °C

4.1: hydrazine hydrate / 20 °C

4.2: 1 h / 0 - 20 °C

5.1: dichloromethane / 20 °C

5.2: 5 h

With hydrogen; magnesium sulfate; hydrazine hydrate; palladium 10% on activated carbon; In dichloromethane; ethyl acetate;

upstream raw materials:

4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzaldehyde

tert-butyl 2-methylpiperazine-1-carboxylate

3-nitrophthalic acid anhydride

di-tert-butyl dicarbonate

Downstream raw materials:

9-(4-fluorophenyl)-8-(4-((3-methylpiperazin-1-yl)methyl)phenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one