Technology Process of ((4R,5R,6S,7S,Z)-6-(4-methoxybenzyloxy)-1-iodo-5,7-dimethylundeca-8,10-dien-4-yloxy)(tert-butyl)dimethylsilane
There total 11 articles about ((4R,5R,6S,7S,Z)-6-(4-methoxybenzyloxy)-1-iodo-5,7-dimethylundeca-8,10-dien-4-yloxy)(tert-butyl)dimethylsilane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1H-imidazole; iodine; triphenylphosphine;
In
diethyl ether; benzene;
at 20 ℃;
for 0.666667h;
DOI:10.1021/jm061385k
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: Et2BOMe / tetrahydrofuran; methanol / 0.67 h / -78 °C
1.2: 85 percent / NaBH4 / tetrahydrofuran; methanol / 7.17 h / -78 °C
2.1: 60 percent / DDQ; molecular sieves 4 Angstroem / CH2Cl2 / 2 h / 0 - 20 °C
3.1: 99 percent / 2,6-lutidine / CH2Cl2 / 1.5 h / -78 - 0 °C
4.1: 41 percent / DIBALH / CH2Cl2; hexane / 12.5 h / -78 - -45 °C
5.1: triethylamine; SO3*pyridine / CH2Cl2; dimethylsulfoxide / 1.17 h / 0 °C
6.1: CrCl2 / tetrahydrofuran / 17 h / 20 °C
7.1: 1.85 g / NaH / tetrahydrofuran / 1.3 h / 0 - 20 °C
8.1: 75 percent / HF*pyridine; pyridine / tetrahydrofuran / 6 h / 0 - 20 °C
9.1: 93 percent / triphenylphosphine; imidazole; I2 / benzene; diethyl ether / 0.67 h / 20 °C
With
pyridine; 1H-imidazole; 2,6-dimethylpyridine; chromium dichloride; pyridine-SO3 complex; 4 A molecular sieve; diethyl methoxy borane; iodine; sodium hydride; diisobutylaluminium hydride; pyridine hydrogenfluoride; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; benzene;
6.1: Nozaki-Hiyama-Kishi reaction / 7.1: Peterson elimination;
DOI:10.1021/jm061385k
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 41 percent / DIBALH / CH2Cl2; hexane / 12.5 h / -78 - -45 °C
2: triethylamine; SO3*pyridine / CH2Cl2; dimethylsulfoxide / 1.17 h / 0 °C
3: CrCl2 / tetrahydrofuran / 17 h / 20 °C
4: 1.85 g / NaH / tetrahydrofuran / 1.3 h / 0 - 20 °C
5: 75 percent / HF*pyridine; pyridine / tetrahydrofuran / 6 h / 0 - 20 °C
6: 93 percent / triphenylphosphine; imidazole; I2 / benzene; diethyl ether / 0.67 h / 20 °C
With
pyridine; 1H-imidazole; chromium dichloride; pyridine-SO3 complex; iodine; sodium hydride; diisobutylaluminium hydride; pyridine hydrogenfluoride; triethylamine; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; benzene;
3: Nozaki-Hiyama-Kishi reaction / 4: Peterson elimination;
DOI:10.1021/jm061385k
