1-{[5-(3-cyano-phenyl)-6-methoxy-pyridine-3-carbonyl]-amino}-cycloheptanecarboxylic acid methyl ester

Base Information

Chemical Name:1-{[5-(3-cyano-phenyl)-6-methoxy-pyridine-3-carbonyl]-amino}-cycloheptanecarboxylic acid methyl ester
CAS No.:1298046-50-0
Molecular Formula:C₂₃H₂₅N₃O₄
Molecular Weight:407.469
Hs Code.:

Synonyms:1-{[5-(3-cyano-phenyl)-6-methoxy-pyridine-3-carbonyl]-amino}-cycloheptanecarboxylic acid methyl ester

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Chemical Property of 1-{[5-(3-cyano-phenyl)-6-methoxy-pyridine-3-carbonyl]-amino}-cycloheptanecarboxylic acid methyl ester

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Technology Process of 1-{[5-(3-cyano-phenyl)-6-methoxy-pyridine-3-carbonyl]-amino}-cycloheptanecarboxylic acid methyl ester

There total 4 articles about 1-{[5-(3-cyano-phenyl)-6-methoxy-pyridine-3-carbonyl]-amino}-cycloheptanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1298046-49-7
1-{[5-bromo-6-methoxy-pyridine-3-carbonyl]-amino}-cycloheptanecarboxylic acid methyl ester

: 150255-96-2
(3‐cyanophenyl)boronic acid

: 1298046-50-0
1-{[5-(3-cyano-phenyl)-6-methoxy-pyridine-3-carbonyl]-amino}-cycloheptanecarboxylic acid methyl ester

Guidance literature:: With potassium fluoride; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 50 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1186194-46-6
5-bromo-6-methoxypyridine-3-carboxylic acid

: 1298046-50-0
1-{[5-(3-cyano-phenyl)-6-methoxy-pyridine-3-carbonyl]-amino}-cycloheptanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 0.5 h / 60 °C / Inert atmosphere

2: sodium hydrogencarbonate / dichloromethane; ethyl acetate

3: potassium fluoride; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 50 °C / Inert atmosphere

With potassium fluoride; thionyl chloride; sodium hydrogencarbonate; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; ethyl acetate;

Reference yield:

: C₇H₅BrClNO₂

: 1298046-50-0
1-{[5-(3-cyano-phenyl)-6-methoxy-pyridine-3-carbonyl]-amino}-cycloheptanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dichloromethane; ethyl acetate

2: potassium fluoride; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 2 h / 50 °C / Inert atmosphere

With potassium fluoride; sodium hydrogencarbonate; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; ethyl acetate;