5-Bromo-6-methoxynicotinic acid methyl ester

Base Information

• Chemical Name: 5-Bromo-6-methoxynicotinic acid methyl ester
• CAS No.: 93349-99-6
• Molecular Formula: C8H8BrNO3
• Molecular Weight: 246.06
• Hs Code.: 2933399990
• Mol file: 93349-99-6.mol

Synonyms:5-Bromo-6-methoxynicotinic acid methyl ester

Chemical Property of 5-Bromo-6-methoxynicotinic acid methyl ester

Chemical Property:

• Vapor Pressure: 0.00529mmHg at 25°C
• Refractive Index: 1.54
• Boiling Point: 274.8°C at 760 mmHg
• PKA: -0.99±0.20(Predicted)
• Flash Point: 120°C
• PSA: 48.42000
• Density: 1.53g/cm³
• LogP: 1.63930
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-Bromo-6-methoxynicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-6-methoxynicotinic acid methyl ester

There total 9 articles about 5-Bromo-6-methoxynicotinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

sodium methylate (124-41-4) + 5-bromo-6-chloro-3-pyridinecarboxylic acid methyl ester (78686-77-8) → methyl 5-bromo-6-methoxy-pyridine-3-carboxylate (93349-99-6)

Guidance literature:

In methanol; for 0.5h;

DOI:10.1021/jo00200a045

Reference yield: 39.0%

ethyl 5,6-dibromonicotinate (1190862-68-0) + sodium methylate (124-41-4) → methyl 5-bromo-6-methoxy-pyridine-3-carboxylate (93349-99-6)

Guidance literature:

With methanol; at 85 ℃; for 48h; Sealed tube;

Reference yield:

6-hydroxy-3-pyridinecarboxylic acid (5006-66-6) + sodium methylate (124-41-4) → methyl 5-bromo-6-methoxy-pyridine-3-carboxylate (93349-99-6)

Guidance literature:

6-hydroxy-3-pyridinecarboxylic acid; With bromine; acetic acid; at 60 ℃; for 16h;

With phosphorus pentachloride; trichlorophosphate; In methanol; at 100 ℃; for 2h;

sodium methylate; In methanol; at 10 - 35 ℃; for 2h;

upstream raw materials:

sodium methylate

5-bromo-6-chloro-3-pyridinecarboxylic acid methyl ester

6-hydroxynicotinic acid

ethyl 5,6-dibromonicotinate

Downstream raw materials:

Methyl 5-(2-Methoxyphenyl)-6-methoxynicotinate

Methyl 5-Phenyl-6-methoxynicotinate

5-bromo-6-methoxypyridine-3-carboxylic acid

1-{[5-(3-cyano-phenyl)-6-methoxy-pyridine-3-carbonyl]-amino}-cycloheptanecarboxylic acid methyl ester