[5-methyl-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole-4-yl]methanol

Base Information

• Chemical Name: [5-methyl-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole-4-yl]methanol
• CAS No.: 870788-49-1
• Molecular Formula: C₁₁H₁₀F₃N₃O
• Molecular Weight: 257.215
• Mol file: 870788-49-1.mol

Synonyms:[5-methyl-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole-4-yl]methanol

Chemical Property of [5-methyl-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole-4-yl]methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [5-methyl-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole-4-yl]methanol

There total 1 articles about [5-methyl-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole-4-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-trifluoromethylphenylamine (455-14-1) → [5-methyl-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole-4-yl]methanol (870788-49-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogenchloride / water; acetic acid / 0 °C

1.2: 2 h / 0 - 20 °C

1.3: 20 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; sodium nitrite; In tetrahydrofuran; water; acetic acid;

DOI:10.1021/acs.jmedchem.1c00560

Reference yield: 55.8%

[5-methyl-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole-4-yl]methanol (870788-49-1) → 4-(chloromethyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole (870788-52-6)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 4 ℃; for 24h;

DOI:10.1021/acs.jmedchem.1c00560

Reference yield:

[5-methyl-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole-4-yl]methanol (870788-49-1) → 4-bromomethyl-5-methyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3]triazole (870788-50-4)

Guidance literature:

With hydrogen bromide; In acetic acid; at 100 ℃; for 2h;

upstream raw materials:

4-trifluoromethylphenylamine

Downstream raw materials:

4-bromomethyl-5-methyl-2-(4-trifluoromethyl-phenyl)-2H-[1,2,3]triazole

4-(chloromethyl)-5-methyl-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole