4-ethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-(pyridin-3-yl)thiazol-2-ylamino)benzamide

Base Information

• Chemical Name: 4-ethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-(pyridin-3-yl)thiazol-2-ylamino)benzamide
• CAS No.: 1290090-14-0
• Molecular Formula: C₂₈H₂₃F₃N₆OS
• Molecular Weight: 548.591

Synonyms:4-ethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-(pyridin-3-yl)thiazol-2-ylamino)benzamide

Chemical Property of 4-ethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-(pyridin-3-yl)thiazol-2-ylamino)benzamide

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Technology Process of 4-ethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-(pyridin-3-yl)thiazol-2-ylamino)benzamide

There total 4 articles about 4-ethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-(pyridin-3-yl)thiazol-2-ylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline (641571-11-1) + C18H17N3O2S (1290090-08-2) → 4-ethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-(pyridin-3-yl)thiazol-2-ylamino)benzamide (1290090-14-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at -20 - 20 ℃;

DOI:10.1016/j.bmcl.2011.02.029

Reference yield:

[3-bromo-5-(trifluoromethyl)phenyl]amine (54962-75-3) → 4-ethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-(pyridin-3-yl)thiazol-2-ylamino)benzamide (1290090-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; 1-(5,6,7,8-tetrahydroquinolin-8-yl)ethan-1-one; caesium carbonate / N,N-dimethyl-formamide / 24 h / 130 °C / Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran / -20 - 20 °C

With copper(l) iodide; 1-(5,6,7,8-tetrahydroquinolin-8-yl)ethan-1-one; potassium tert-butylate; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.02.029

Reference yield:

3-amino-4-ethylbenzoic acid methyl ester (24812-93-9) → 4-ethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(4-(pyridin-3-yl)thiazol-2-ylamino)benzamide (1290090-14-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetone / 1 h / 40 °C

1.2: 5 h / 20 °C

2.1: potassium carbonate / methanol / 0.08 h / 20 °C

2.2: 3 h / 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / -20 - 20 °C

With potassium tert-butylate; potassium carbonate; In tetrahydrofuran; methanol; acetone;

DOI:10.1016/j.bmcl.2011.02.029

upstream raw materials:

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

C₁₈H₁₇N₃O₂S

3-Bromoacetylpyridine

C₁₃H₁₆N₂O₃S

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