(R)-tert-butyl 1-(3-((4-chlorophenyl)carbamoyl)pyridin-2-ylamino)-1-oxopropan-2-ylcarbamate

Base Information

Chemical Name:(R)-tert-butyl 1-(3-((4-chlorophenyl)carbamoyl)pyridin-2-ylamino)-1-oxopropan-2-ylcarbamate
CAS No.:1262796-98-4
Molecular Formula:C₂₀H₂₃ClN₄O₄
Molecular Weight:418.88
Hs Code.:

Synonyms:(R)-tert-butyl 1-(3-((4-chlorophenyl)carbamoyl)pyridin-2-ylamino)-1-oxopropan-2-ylcarbamate

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Chemical Property of (R)-tert-butyl 1-(3-((4-chlorophenyl)carbamoyl)pyridin-2-ylamino)-1-oxopropan-2-ylcarbamate

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Technology Process of (R)-tert-butyl 1-(3-((4-chlorophenyl)carbamoyl)pyridin-2-ylamino)-1-oxopropan-2-ylcarbamate

There total 3 articles about (R)-tert-butyl 1-(3-((4-chlorophenyl)carbamoyl)pyridin-2-ylamino)-1-oxopropan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1262797-00-1
(R)-methyl 2-(2-(N-(tert-butoxycarbonyl)amino)propanamido)nicotinate

: 106-47-8
4-chloro-aniline

: 1262796-98-4
(R)-tert-butyl 1-(3-((4-chlorophenyl)carbamoyl)pyridin-2-ylamino)-1-oxopropan-2-ylcarbamate

Guidance literature:: With isopropylmagnesium chloride; In tetrahydrofuran; at 2 - 25 ℃; optical yield given as %ee;
DOI:10.1021/jo102399a

Reference yield:

: 40134-18-7
methyl 2-chloropyridine-3-carboxylate

: 1262796-98-4
(R)-tert-butyl 1-(3-((4-chlorophenyl)carbamoyl)pyridin-2-ylamino)-1-oxopropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 16 h / Inert atmosphere; Reflux

2: isopropylmagnesium chloride / tetrahydrofuran / 2 - 25 °C

With isopropylmagnesium chloride; palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran;
DOI:10.1021/jo102399a

Reference yield:

: 78981-25-6
N-(tert-butoxycarbonyl)-D-alanine amide

: 1262796-98-4
(R)-tert-butyl 1-(3-((4-chlorophenyl)carbamoyl)pyridin-2-ylamino)-1-oxopropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 16 h / Inert atmosphere; Reflux

2: isopropylmagnesium chloride / tetrahydrofuran / 2 - 25 °C

With isopropylmagnesium chloride; palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran;
DOI:10.1021/jo102399a