Technology Process of tert-butyl 2-((2R,4R,6R)-6-(2-(diallylamino)ethyl)-2-phenyl-1,3-dioxan-4-yl)acetate
There total 5 articles about tert-butyl 2-((2R,4R,6R)-6-(2-(diallylamino)ethyl)-2-phenyl-1,3-dioxan-4-yl)acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium tert-butylate;
In
tetrahydrofuran;
at 0 ℃;
for 1.5h;
enantioselective reaction;
Inert atmosphere;
DOI:10.1002/chem.201204609
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: mesitylcopper(I); (R,R)-1,2-bis(2,5-diphenylphospholanyl)ethane; 2,2,5,7,8-pentamethylchroman-6-ol / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / -40 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / -78 - 20 °C / Inert atmosphere
3.1: rochelle salt / water / 2.5 h / 20 °C / Inert atmosphere
3.2: 1 h / 0 - 20 °C / Inert atmosphere
4.1: manganese(IV) oxide / toluene / 14 h / Inert atmosphere; Reflux
5.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere
With
manganese(IV) oxide; lithium aluminium tetrahydride; 2,2,5,7,8-pentamethylchroman-6-ol; mesitylcopper(I); potassium tert-butylate; rochelle salt; (R,R)-1,2-bis(2,5-diphenylphospholanyl)ethane;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/chem.201204609
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: rochelle salt / water / 2.5 h / 20 °C / Inert atmosphere
1.2: 1 h / 0 - 20 °C / Inert atmosphere
2.1: manganese(IV) oxide / toluene / 14 h / Inert atmosphere; Reflux
3.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere
With
manganese(IV) oxide; potassium tert-butylate; rochelle salt;
In
tetrahydrofuran; water; toluene;
DOI:10.1002/chem.201204609
