(S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester

Base Information

Chemical Name:(S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester
CAS No.:156078-80-7
Molecular Formula:C₃₀H₃₂Cl₂N₂O₆
Molecular Weight:587.5
Hs Code.:

Synonyms:(S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester

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Chemical Property of (S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester

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Technology Process of (S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester

There total 3 articles about (S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 2791-84-6,227205-81-4
L-glutamic acid dibenzyl ester 4-toluenesulfonate

: 156078-81-8
carbonic acid p-(bis-2-chloroethylamino)phenol ester-p-nitrophenyl ester

: 156078-80-7
(S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester

Guidance literature:: With triethylamine; In chloroform; at 60 ℃; for 4h;
DOI:10.1021/jm950671l

Reference yield:

: 1457-06-3
4-[N,N-bis(2-chloroethyl)amino]phenol hydrochloride

: 156078-80-7
(S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaHCO₃, quinoline / toluene / 1 h / Ambient temperature

2: Et₃N / CHCl₃ / 1 h / Ambient temperature

With quinoline; sodium hydrogencarbonate; triethylamine; In chloroform; toluene;
DOI:10.1021/jm950671l