1457-06-3

Usage

Uses

Used in Oncology:
Used in Cancer Research:
In addition to its clinical applications, Phenol, 4-[bis(2-chloroethyl)amino]-, hydrochloride (1:1) is also used in cancer research to study the mechanisms of action of alkylating agents and to develop new strategies for cancer treatment. Its cytotoxic properties make it a valuable tool for investigating the effects of DNA damage on cancer cells and for identifying potential targets for therapeutic intervention.
Used in Drug Development:
Phenol, 4-[bis(2-chloroethyl)amino]-, hydrochloride (1:1) serves as a starting point for the development of new anticancer drugs. Its unique chemical structure and alkylating properties provide a foundation for the design of novel compounds with improved selectivity, efficacy, and reduced toxicity. Researchers are working to modify the structure of Phenol,4-[bis(2-chloroethyl)amino]-, hydrochloride (1:1) to develop more targeted therapies that can selectively kill cancer cells while minimizing damage to healthy tissues.
Used in Drug Delivery Systems:
To overcome the limitations of Phenol, 4-[bis(2-chloroethyl)amino]-, hydrochloride (1:1), such as its high toxicity and side effects, researchers are developing drug delivery systems to improve its therapeutic index. These systems, which may include liposomes, nanoparticles, or other carriers, aim to enhance the delivery of the compound to cancer cells, increase its bioavailability, and reduce its impact on healthy tissues.

Upstream product

• 17794-35-3 benzyl-p-(bis-2-chloroethylamino)phenyl ester 
• 101582-69-8 4--O-benzylphenol 
• 51388-20-6 4-benzyloxyaniline hydrochloride 
• 6373-46-2 p-benzyloxyaniline 

Downstream Products

• 52177-49-8 4-[N,N-bis(2-chloroethyl)amino]phenyl chloroformate 
• 156078-81-8 carbonic acid p-(bis-2-chloroethylamino)phenol ester-p-nitrophenyl ester 
• 174579-29-4 Thiocarbonic acid O-{4-[bis-(2-chloro-ethyl)-amino]-phenyl} ester O-pentafluorophenyl ester 
• 209158-08-7 {2'-(3'',4''-dihydroxyphenyl)ethyl} carbamic acid p-(bis-2-chloroethylamino)phenyl ester 
• 209158-13-4 {2'-(4''-hydroxyphenyl)ethyl} carbamic acid p-(bis-2-chloroethylamino)phenyl ester 
• 371754-24-4 {2'-(4''-hydroxyphenoxy)ethylamine} carbamic acid p-(bis-2-chloroethylamino)phenyl ester 
• 371754-25-5 {2'-[(4''-hydroxyphenyl)thio]ethylamine} carbamic acid p-(bis-2-chloroethylamino)phenyl ester 
• 371754-20-0 3',4'-dihydroxybenzylamino-carbamic acid p-(bis-2-chloroethylamino)phenyl ester 
• 371754-15-3 (S)-[2'-amino-3'-(4''-hydroxyphenyl)propionic acid methyl ester]-carbamic acid p-(bis-2-chloroethylamino)phenyl ester 
• 371754-26-6 (S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-phenoxythiocarbonylamino}-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 371754-23-3 (R)-[1'-amino-2'-hydroxy-2'-(4''-hydroxyphenyl)propionic acid methyl ester]-carbamic acid p-(bis-2-chloroethylamino)phenyl ester 
• 156078-79-4 4-[N,N-bis(2-chloroethyl)amino]-phenoxycarbonyl-L-glutamic acid 
• 156078-80-7 (S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-phenoxycarbonylamino}-pentanedioic acid dibenzyl ester 
• 1196073-08-1 C₁₁H₁₄Cl₃NO₃S 

Relevant academic research and scientific papers

HYPOXIA ACTIVATED DRUGS OF NITROGEN MUSTARD ALKYLATORS

Hypoxia activated drug compounds having a structure of formula(I) are useful in the treatment of cancer and other hyperproliferative diseases.

Melanocyte-directed enzyme prodrug therapy (MDEPT): Development of second generation prodrugs for targeted treatment of malignant melanoma

Evaluation of second generation prodrugs for MDEPT, by oximetry, has highlighted structural properties that are advantageous and disadvantageous for efficient oxidation using mushroom tyrosinase. In particular, a sterically undemanding prodrug bis-(2-chlo

Melanocyte-directed enzyme prodrug therapy (MDEPT): Development of a targeted treatment for malignant melanoma

A novel prodrug rationally designed to function as a tyrosinase substrate has been synthesised to allow targeted treatment of malignant melanoma. This agent has been evaluated for tyrosinase-mediated drug release, and has been shown to act in the desired