3-(1-tert-butoxycarbonyl-2-oxo-3-phenyl-2,3-dihydro-1H-indol-3-yl)propionaldehyde

Base Information

Chemical Name:3-(1-tert-butoxycarbonyl-2-oxo-3-phenyl-2,3-dihydro-1H-indol-3-yl)propionaldehyde
CAS No.:1175713-30-0
Molecular Formula:C₂₂H₂₃NO₄
Molecular Weight:365.429
Hs Code.:

Synonyms:3-(1-tert-butoxycarbonyl-2-oxo-3-phenyl-2,3-dihydro-1H-indol-3-yl)propionaldehyde

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Chemical Property of 3-(1-tert-butoxycarbonyl-2-oxo-3-phenyl-2,3-dihydro-1H-indol-3-yl)propionaldehyde

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Technology Process of 3-(1-tert-butoxycarbonyl-2-oxo-3-phenyl-2,3-dihydro-1H-indol-3-yl)propionaldehyde

There total 2 articles about 3-(1-tert-butoxycarbonyl-2-oxo-3-phenyl-2,3-dihydro-1H-indol-3-yl)propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 862906-97-6
tert-butyl 2-oxo-3-phenylindoline-1-carboxylate

: 107-02-8,25068-14-8
acrolein

: 1175713-30-0
3-(1-tert-butoxycarbonyl-2-oxo-3-phenyl-2,3-dihydro-1H-indol-3-yl)propionaldehyde

Guidance literature:: With C₃₉H₂₈N₂O₅P⁽¹⁺⁾*Br^(1-); In water; 1,3,5-trimethyl-benzene; at 0 ℃; for 48h; Reagent/catalyst; enantioselective reaction;
DOI:10.1039/c3sc22130j

Reference yield:

: 862906-97-6
tert-butyl 2-oxo-3-phenylindoline-1-carboxylate

: 107-02-8,25068-14-8
acrolein

: 1175713-30-0
3-(1-tert-butoxycarbonyl-2-oxo-3-phenyl-2,3-dihydro-1H-indol-3-yl)propionaldehyde

: 1453221-33-4
(R)-tert-butyl 3-(2-formylethyl)-2-oxo-3-phenylindoline-1-carboxylate

Guidance literature:: With C₃₉H₂₈F₂OP⁽¹⁺⁾*Br^(1-); In water; 1,3,5-trimethyl-benzene; at 0 ℃; for 24h; enantioselective reaction;
DOI:10.1039/c3sc22130j

Reference yield: 60.0%

: 1175713-30-0
3-(1-tert-butoxycarbonyl-2-oxo-3-phenyl-2,3-dihydro-1H-indol-3-yl)propionaldehyde

: 593-51-1
methylamine hydrochloride

: 1175713-33-3
1-methyl-4a-phenyl-2,3,4,4a,9,9a-hexahydro-1H-pyrido[2,3-b]indole

Guidance literature:: 3-(1-tert-butoxycarbonyl-2-oxo-3-phenyl-2,3-dihydro-1H-indol-3-yl)propionaldehyde; methylamine hydrochloride; With magnesium sulfate; triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 70 ℃; optical yield given as %ee;