2-<(4R,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole

Base Information

• Chemical Name: 2-<(4R,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole
• CAS No.: 152500-41-9
• Molecular Formula: C₂₂H₂₆O₅
• Molecular Weight: 370.445
• Mol file: 152500-41-9.mol

Synonyms:2-<(4R,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole

Chemical Property of 2-<(4R,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<(4R,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole

There total 3 articles about 2-<(4R,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-<1-<(4R,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolan-4-yl>-1-hydroxymethyl>-3-methylanisole → 2-<(4R,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole (152500-41-9)

Guidance literature:

With pyridine; chromium(VI) oxide; In dichloromethane; for 0.75h; Ambient temperature;

DOI:10.1016/S0040-4020(01)80644-X

Reference yield:

2-bromo-3-methylanisole (38197-43-2) → 2-<(4R,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole (152500-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / n-butyllihium / hexane; diethyl ether / 0.75 h / -78 °C

2: 98 percent / pyridine, chromium (VI) oxide / CH₂Cl₂ / 0.75 h / Ambient temperature

With pyridine; chromium(VI) oxide; n-butyllithium; In diethyl ether; hexane; dichloromethane;

DOI:10.1016/S0040-4020(01)80644-X

Reference yield:

4-O-benzyl-2,3-O-isopropylidene-D-threose (81801-09-4) → 2-<(4R,5R)-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole (152500-41-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / n-butyllihium / hexane; diethyl ether / 0.75 h / -78 °C

2: 98 percent / pyridine, chromium (VI) oxide / CH₂Cl₂ / 0.75 h / Ambient temperature

With pyridine; chromium(VI) oxide; n-butyllithium; In diethyl ether; hexane; dichloromethane;

DOI:10.1016/S0040-4020(01)80644-X

upstream raw materials:

2-bromo-3-methylanisole

4-O-benzyl-2,3-O-isopropylidene-D-threose

Downstream raw materials:

2-<(4S,5R)-5-hydroxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole

(-)-quinocarcin

2-<(4S,5R)-5-methoxymethoxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbonyl>-3-methylanisole

(2S,5R)-2-Benzyloxymethyl-5-((1R,5S,10bR)-1-hydroxymethyl-10-methoxy-3-oxo-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-5-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester