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2-Bromo-1-methoxy-3-methylbenzene, also known as 5-bromo-2-methylanisole, is a synthetic organic compound belonging to the class of aromatic compounds known as benzene and its derivatives. Identified with the CAS Registry Number 6071-25-6, this chemical appears as a granular, crystalline powder or solid in its pure form. It is primarily used in the field of organic synthesis and requires adequate safety measures in handling and storage due to its potentially hazardous nature.

38197-43-2

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38197-43-2 Usage

Uses

Used in Organic Synthesis:
2-Bromo-1-methoxy-3-methylbenzene is used as a synthetic intermediate in the organic synthesis industry for the production of various chemical compounds. Its unique structure and functional groups make it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Bromo-1-methoxy-3-methylbenzene is used as a key intermediate in the synthesis of various drug molecules. Its presence in the molecular structure can impart specific biological activities and properties to the final drug product, making it an essential component in the development of new medications.
Used in Agrochemical Industry:
2-Bromo-1-methoxy-3-methylbenzene is also utilized in the agrochemical industry as a precursor for the synthesis of various agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness in controlling pests and weeds, thereby contributing to increased crop yields and agricultural productivity.
Used in Specialty Chemicals:
In the specialty chemicals sector, 2-Bromo-1-methoxy-3-methylbenzene is employed as a raw material for the production of various specialty chemicals, including dyes, fragrances, and flavoring agents. Its unique chemical properties allow it to impart specific characteristics to these products, making it a valuable component in their formulation.

Check Digit Verification of cas no

The CAS Registry Mumber 38197-43-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,1,9 and 7 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 38197-43:
(7*3)+(6*8)+(5*1)+(4*9)+(3*7)+(2*4)+(1*3)=142
142 % 10 = 2
So 38197-43-2 is a valid CAS Registry Number.

38197-43-2Relevant articles and documents

Studies toward the Total Syntheses of Calyciphylline D-Type Daphniphyllum Alkaloids

Cui, Yi,Ren, Jun,Lv, Jiayuan,Wang, Zhongwen

supporting information, p. 9189 - 9193 (2021/11/30)

An efficient construction of an aza-[5.7.6.5] tetracyclic core structure of calyciphylline D-type Daphniphyllum alkaloids has been achieved. The synthetic route features a diastereoselective cyclopropanation, efficient construction of the core bridged 8-aza-[3.2.1]octane skeleton through a [3 + 2] IMCC strategy, oxidative dearomatization of phenol, and gram-scale preparation in each step.

ACYLAMINO BRIDGED HETEROCYCLIC COMPOUND, AND COMPOSITION AND APPLICATION THEREOF

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Paragraph 0174, (2021/11/04)

Provided are an acylamino bridged heterocyclic compound of formula (I) or a pharmaceutically acceptable salt, an isomer, a solvate, a crystal, or a prodrug thereof, and a pharmaceutical composition comprising the compound, and an application of the compou

ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4)(BETA7)

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Paragraph 0228; 0775; 0776, (2019/10/29)

Disclosed are small molecule antagonists of α4β7 integrin, and methods of using them to treat a number of specific diseases or conditions.

1,2-asymmetric induction in diastereoselective zwitterionic aza-Claisen rearrangements: Key steps in optically active alkaloid synthesis

Heescher, Carolin,Schollmeyer, Dieter,Nubbemeyer, Udo

supporting information, p. 4399 - 4404 (2013/07/26)

The zwitterionic aza-Claisen rearrangement of optically active N-allylpyrrolidines and α-phenoxyacetyl fluorides proceeds with complete simple diastereoselectivity (internal asymmetric induction) and complete 1,2-asymmetric induction to generate a new C-C bond adjacent to a chiral C-N-Boc functionality. The resulting γ,δ-unsaturated amides were cyclised to give the corresponding pyrrolizidinones, which enabled the determination of the relative configuration of the stereotriads. Vinyl group degradation and a final lactam reduction gave an optically active analogue of (+)-petasinine (a pyrrolizidine alkaloid). Furthermore, the stereotriad-containing amides should be useful key intermediates for the total synthesis of optically active elaeocarpin (an indolizidine alkaloid). Copyright

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

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Page/Page column 70, (2013/07/05)

The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.

Design of living ring-opening alkyne metathesis

Fischer, Felix R.,Nuckolls, Colin

supporting information; experimental part, p. 7257 - 7260 (2010/11/05)

It's alive: A ring-strained alkyne based on dibenzo[a,e][8]annulene undergoes ringopening metathesis polymerization (ROMP) to give a high-molecular-weight poly(ortho-phenylene) featuring alternating ethyl and ethynyl linkers along the polymer backbone. The molybdenumalkylidyne- based catalyst system discriminates between strained and unstrained alkynes to yield a living polymer with an unparalleled low polydispersity.

Reaction of methyl 4,5-epoxy-(2E)-pentenoate with arylcopper reagents

Nagumo,Irie,Akita

, p. 675 - 680 (2007/10/03)

The reaction of methyl 4,5-epoxy-(2E)-pentenoate (1) with various arylcopper reagents was studied. Basically, all arylcopper reagents react with 1 in SN2 fashion. However, addition of BF3 causes reversal of the regioselectivity, which can be ra

Collisionally induced dissociation in the study of A-ring hydroxylated vitamin D type compounds

Young, David C.,Vouros, Paul,Holick, Michael F.,Higuchi, Tetsuo

, p. 837 - 842 (2007/10/02)

Colllslonally Induced dissociation (CID) is often used to determine the structure of ions based on comparison with the CID spectra of known ions. The latter are generated from Judiciously selected compounds taking into account basic principles of Ion chemistry. We report here on the use of this approach toward determination of the site of A-ring hydroxylation of vitamin D. Although not Intrinsically an aromatic compound, vitamin D gives rise in its mass spectrum to an aromatic methytstyryl cation at mlz 118. A-ring hydroxylated metabolites of vitamin D would thus Incorporate the extra OH group on the ion at mlz 118, shifting it to mlz 134. The position of substitution of the extra OH group on a metabolite could then be ascertained by comparing the CID spectrum of its mlz 134 fragment to those of the four possible (hydroxymethyl)styryl cations generated from synthesized authentic compounds. Because of their propensity to polymerize, these cations were generated in situ via the McLafferty rearrangement of the corresponding (hydroxyphenyl)ethanols. For optimum differentiation of Isomeric Ions, preparation of permethylated derivatives of vitamin D was necessary. The validity of the hypothesis was verified using 1,25-dihydroxy-vitamin D3 as a test compound. This method provides a viable approach for the characterization of A-ring hydroxylated metabolites of vitamin D as well as for related aromatic compounds.

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