Technology Process of 3-(4-methoxyphenyl)-7-methyl-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one
There total 5 articles about 3-(4-methoxyphenyl)-7-methyl-4'H-spiro[isoindole-1,1'-naphthalen]-4'-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,10-Phenanthroline; water; copper diacetate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 20h;
under 760.051 Torr;
DOI:10.1021/ol301583y
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydroxylamine hydrochloride / dimethyl sulfoxide / 3 h / 100 °C
2.1: diethyl ether / 2 h / 80 °C / Cooling with ice
2.2: 0 °C
3.1: 1,10-Phenanthroline; water; copper diacetate / N,N-dimethyl-formamide / 20 h / 20 °C / 760.05 Torr
With
1,10-Phenanthroline; hydroxylamine hydrochloride; water; copper diacetate;
In
diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ol301583y
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane / Inert atmosphere; Reflux
2.1: hydroxylamine hydrochloride / dimethyl sulfoxide / 3 h / 100 °C
3.1: diethyl ether / 2 h / 80 °C / Cooling with ice
3.2: 0 °C
4.1: 1,10-Phenanthroline; water; copper diacetate / N,N-dimethyl-formamide / 20 h / 20 °C / 760.05 Torr
With
tetrakis(triphenylphosphine) palladium(0); 1,10-Phenanthroline; hydroxylamine hydrochloride; water; copper diacetate;
In
1,2-dimethoxyethane; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide;
1.1: Suzuki-Miyaura cross coupling reaction;
DOI:10.1021/ol301583y
