3-benzyloxyestra-1,3,5⁽¹⁰⁾-triene-[17,16-c]-(1'-methyl acetate)pyrazole

Base Information

Chemical Name:3-benzyloxyestra-1,3,5⁽¹⁰⁾-triene-[17,16-c]-(1'-methyl acetate)pyrazole
CAS No.:769957-16-6
Molecular Formula:C₂₉H₃₂N₂O₃
Molecular Weight:456.585
Hs Code.:

3-benzyloxyestra-1,3,5<sup>(10)</sup>-triene-[17,16-c]-(1'-methyl acetate)pyrazole

Synonyms:3-benzyloxyestra-1,3,5⁽¹⁰⁾-triene-[17,16-c]-(1'-methyl acetate)pyrazole

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Chemical Property of 3-benzyloxyestra-1,3,5⁽¹⁰⁾-triene-[17,16-c]-(1'-methyl acetate)pyrazole

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Technology Process of 3-benzyloxyestra-1,3,5⁽¹⁰⁾-triene-[17,16-c]-(1'-methyl acetate)pyrazole

There total 6 articles about 3-benzyloxyestra-1,3,5⁽¹⁰⁾-triene-[17,16-c]-(1'-methyl acetate)pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 769957-11-1
3-benzyloxyestra-1,3,5⁽¹⁰⁾-triene-[17,16-c]-pyrazole

: 96-34-4
methyl chloroacetate

: 769957-16-6
3-benzyloxyestra-1,3,5⁽¹⁰⁾-triene-[17,16-c]-(1'-methyl acetate)pyrazole

: 769957-17-7
3-benzyloxyestra-1,3,5⁽¹⁰⁾-triene-[17,16-c]-(2'-methyl acetate)pyrazole

Guidance literature:: 3-benzyloxyestra-1,3,5⁽¹⁰⁾-triene-[17,16-c]-pyrazole; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

methyl chloroacetate; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h;
DOI:10.1021/jm050348a

Reference yield: 48.0%

: 769957-16-6
3-benzyloxyestra-1,3,5⁽¹⁰⁾-triene-[17,16-c]-(1'-methyl acetate)pyrazole

: 769957-17-7
3-benzyloxyestra-1,3,5⁽¹⁰⁾-triene-[17,16-c]-(2'-methyl acetate)pyrazole

Guidance literature:

Reference yield:

: 53-16-7
Estrone

: 769957-16-6
3-benzyloxyestra-1,3,5⁽¹⁰⁾-triene-[17,16-c]-(1'-methyl acetate)pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide

2.1: t-BuOK / toluene / 0.33 h / 20 °C

2.2: 86 percent / toluene / 2.5 h / 20 °C

3.1: 94 percent / hydrazine hydrate / ethanol / 0.75 h / Heating

4.1: NaH / dimethylformamide / 0.33 h / 0 °C

4.2: 48 percent / dimethylformamide / 2.5 h / 20 °C

With potassium tert-butylate; sodium hydride; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm050348a