tert-butyl {(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-(2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)piperidin-1-yl}carboxylate

Base Information

Chemical Name:tert-butyl {(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-(2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)piperidin-1-yl}carboxylate
CAS No.:1280211-14-4
Molecular Formula:C₂₆H₃₅F₂N₅O₄
Molecular Weight:519.592
Hs Code.:

Synonyms:tert-butyl {(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-(2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)piperidin-1-yl}carboxylate

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Chemical Property of tert-butyl {(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-(2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)piperidin-1-yl}carboxylate

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Technology Process of tert-butyl {(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-(2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)piperidin-1-yl}carboxylate

There total 10 articles about tert-butyl {(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-(2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)piperidin-1-yl}carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: (2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-amine tris(trifluoroacetic acid salt)

: 1280211-14-4
tert-butyl {(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-(2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)piperidin-1-yl}carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 18h;

Reference yield:

: 2646-90-4
2,5-difluorobenzaldehyde

: 1280211-14-4
tert-butyl {(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-(2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)piperidin-1-yl}carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium acetate / ethanol / 16 h / Reflux

2.1: sodium tetrahydroborate / nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

2.2: 15 h / 0 - 20 °C

3.1: N,N,N,N,-tetramethylethylenediamine; trimethylsilyl iodide / dichloromethane / 2 h / 0 °C

3.2: 3 h

3.3: 0.17 h

4.1: N,N,N,N,-tetramethylethylenediamine / dichloromethane; N,N-dimethyl-formamide / 64 h / 20 °C

5.1: dimethylsulfide borane complex / tetrahydrofuran / 1.25 h / 70 °C

5.2: 0.75 h / 0 °C

6.1: hydrogenchloride / water / 24 h

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h

With hydrogenchloride; sodium tetrahydroborate; trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; dimethylsulfide borane complex; ammonium acetate; N-ethyl-N,N-diisopropylamine; nickel (II) chloride hexahydrate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1280210-82-3
(5S,6R)-6-(2,5-difluorophenyl)-5-nitropiperidin-2-one

: 1280211-14-4
tert-butyl {(2R,3S,5R)-3-[(tert-butoxycarbonyl)amino]-2-(2,5-difiuorophenyl)-5-(2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl)piperidin-1-yl}carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

1.2: 15 h / 0 - 20 °C

2.1: N,N,N,N,-tetramethylethylenediamine; trimethylsilyl iodide / dichloromethane / 2 h / 0 °C

2.2: 3 h

2.3: 0.17 h

3.1: N,N,N,N,-tetramethylethylenediamine / dichloromethane; N,N-dimethyl-formamide / 64 h / 20 °C

4.1: dimethylsulfide borane complex / tetrahydrofuran / 1.25 h / 70 °C

4.2: 0.75 h / 0 °C

5.1: hydrogenchloride / water / 24 h

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h

With hydrogenchloride; sodium tetrahydroborate; trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; dimethylsulfide borane complex; N-ethyl-N,N-diisopropylamine; nickel (II) chloride hexahydrate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;