1-phenyl-3-(2-(trimethylsilyl)ethylsulfonyl)-3-aza-bicyclo[3.1.0]hexan-2-one

Base Information

Chemical Name:1-phenyl-3-(2-(trimethylsilyl)ethylsulfonyl)-3-aza-bicyclo[3.1.0]hexan-2-one
CAS No.:1433140-51-2
Molecular Formula:C₁₆H₂₃NO₃SSi
Molecular Weight:337.515
Hs Code.:

Synonyms:1-phenyl-3-(2-(trimethylsilyl)ethylsulfonyl)-3-aza-bicyclo[3.1.0]hexan-2-one

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Chemical Property of 1-phenyl-3-(2-(trimethylsilyl)ethylsulfonyl)-3-aza-bicyclo[3.1.0]hexan-2-one

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Technology Process of 1-phenyl-3-(2-(trimethylsilyl)ethylsulfonyl)-3-aza-bicyclo[3.1.0]hexan-2-one

There total 3 articles about 1-phenyl-3-(2-(trimethylsilyl)ethylsulfonyl)-3-aza-bicyclo[3.1.0]hexan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1433138-89-6
N-allyl-N-(phenylethynyl)-2-(trimethylsilyl)ethanesulfonamide

: 1433140-51-2
1-phenyl-3-(2-(trimethylsilyl)ethylsulfonyl)-3-aza-bicyclo[3.1.0]hexan-2-one

Guidance literature:: With pyridine N-oxide; silver tetrafluoroborate; methanesulfonic acid; [1,3-bis(2,6-di-isopropylphenyl)imidazole-2-ylidenegold(I) chloride]; In 1,2-dichloro-ethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol4007629

Reference yield:

: 1369589-50-3
C₈H₁₉NO₂SSi

: 1433140-51-2
1-phenyl-3-(2-(trimethylsilyl)ethylsulfonyl)-3-aza-bicyclo[3.1.0]hexan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper dichloride; sodium carbonate / 0.25 h

1.2: 0.25 h / 70 °C

1.3: 8 h / 70 °C

2.1: pyridine N-oxide; [1,3-bis(2,6-di-isopropylphenyl)imidazole-2-ylidenegold(I) chloride]; silver tetrafluoroborate; methanesulfonic acid / 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

With pyridine N-oxide; silver tetrafluoroborate; methanesulfonic acid; [1,3-bis(2,6-di-isopropylphenyl)imidazole-2-ylidenegold(I) chloride]; sodium carbonate; copper dichloride; In 1,2-dichloro-ethane;
DOI:10.1021/ol4007629

Reference yield:

: 106018-85-3
2-trimethylsilanyl-ethanesulfonyl chloride

: 1433140-51-2
1-phenyl-3-(2-(trimethylsilyl)ethylsulfonyl)-3-aza-bicyclo[3.1.0]hexan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2.1: copper dichloride; sodium carbonate / 0.25 h

2.2: 0.25 h / 70 °C

2.3: 8 h / 70 °C

3.1: pyridine N-oxide; [1,3-bis(2,6-di-isopropylphenyl)imidazole-2-ylidenegold(I) chloride]; silver tetrafluoroborate; methanesulfonic acid / 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

With pyridine N-oxide; silver tetrafluoroborate; methanesulfonic acid; [1,3-bis(2,6-di-isopropylphenyl)imidazole-2-ylidenegold(I) chloride]; sodium carbonate; triethylamine; copper dichloride; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol4007629