1-(3-azidomethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-(2'-(N-t-butylaminosulfonyl)-[1,1']-biphen-4-yl)carboxamide

Base Information

Chemical Name:1-(3-azidomethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-(2'-(N-t-butylaminosulfonyl)-[1,1']-biphen-4-yl)carboxamide
CAS No.:637318-41-3
Molecular Formula:C₂₉H₃₁N₇O₄S
Molecular Weight:573.676
Hs Code.:

Synonyms:1-(3-azidomethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-(2'-(N-t-butylaminosulfonyl)-[1,1']-biphen-4-yl)carboxamide

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Chemical Property of 1-(3-azidomethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-(2'-(N-t-butylaminosulfonyl)-[1,1']-biphen-4-yl)carboxamide

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Technology Process of 1-(3-azidomethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-(2'-(N-t-butylaminosulfonyl)-[1,1']-biphen-4-yl)carboxamide

There total 11 articles about 1-(3-azidomethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-(2'-(N-t-butylaminosulfonyl)-[1,1']-biphen-4-yl)carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 193006-34-7
4-(2'-tert-butylaminosulfonylphenyl)aniline

: 2-(3-azidomethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carbonyl chloride

: 637318-41-3
1-(3-azidomethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-(2'-(N-t-butylaminosulfonyl)-[1,1']-biphen-4-yl)carboxamide

Guidance literature:: With dmap; triethylamine; In chloroform; at 0 - 20 ℃; for 18h;
DOI:10.1021/jm030212h

Reference yield:

: 3403-47-2
3-amino-6-methoxy-benzoic acid

: 637318-41-3
1-(3-azidomethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-(2'-(N-t-butylaminosulfonyl)-[1,1']-biphen-4-yl)carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: HCl; NaNO₂ / H₂O / 0.5 h / 0 °C

1.2: SnCl₂*2H₂O; HCl / H₂O / 0.25 h / 0 °C

2.1: acetonitrile; H₂O / 3 h / Heating

3.1: N-methylmorpholine / tetrahydrofuran / 0.33 h / 0 °C

4.1: 0.9 g / NaBH₄ / tetrahydrofuran; H₂O / 4 h / 0 - 20 °C

5.1: 0.72 g / Et₃N / CHCl₃ / 18 h / 0 - 20 °C

6.1: NaN₃ / dimethylformamide / 6 h / 60 °C

7.1: 0.17 g / aq. NaOH / ethanol / 4 h / 45 °C

8.1: oxalyl chloride; DMF / CH₂Cl₂; CHCl₃ / 3 h / 0 - 20 °C

9.1: 1.4 g / Et₃N; DMAP / CHCl₃ / 18 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; dmap; sodium hydroxide; sodium tetrahydroborate; sodium azide; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm030212h

Reference yield:

: 615-79-2
ethyl 2,4-diketopentanoate

: 637318-41-3
1-(3-azidomethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-(2'-(N-t-butylaminosulfonyl)-[1,1']-biphen-4-yl)carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: 40 percent / 3A molecular sieves / ethanol / 18 h

2: acetonitrile; H₂O / 3 h / Heating

3: N-methylmorpholine / tetrahydrofuran / 0.33 h / 0 °C

4: 0.9 g / NaBH₄ / tetrahydrofuran; H₂O / 4 h / 0 - 20 °C

5: 0.72 g / Et₃N / CHCl₃ / 18 h / 0 - 20 °C

6: NaN₃ / dimethylformamide / 6 h / 60 °C

7: 0.17 g / aq. NaOH / ethanol / 4 h / 45 °C

8: oxalyl chloride; DMF / CH₂Cl₂; CHCl₃ / 3 h / 0 - 20 °C

9: 1.4 g / Et₃N; DMAP / CHCl₃ / 18 h / 0 - 20 °C

With 4-methyl-morpholine; dmap; sodium hydroxide; sodium tetrahydroborate; sodium azide; oxalyl dichloride; 3 A molecular sieve; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm030212h