benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyridinyl)-1-piperazinecarboxylate

Base Information

Chemical Name:benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyridinyl)-1-piperazinecarboxylate
CAS No.:1450620-42-4
Molecular Formula:C₂₃H₂₁F₆N₃O₃
Molecular Weight:501.428
Hs Code.:

Synonyms:benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyridinyl)-1-piperazinecarboxylate

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Chemical Property of benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyridinyl)-1-piperazinecarboxylate

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Technology Process of benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyridinyl)-1-piperazinecarboxylate

There total 9 articles about benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyridinyl)-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1198169-80-0
2-(6-chloro-3-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 1450620-13-9
benzyl (3S)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

: 1450620-42-4
benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyridinyl)-1-piperazinecarboxylate

Guidance literature:: 2-(6-chloro-3-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol; With hydrogen bromide; acetic acid; In dichloromethane; at 20 - 50 ℃; for 15h;

With sodium hydrogencarbonate; In dichloromethane; water;

benzyl (3S)-3-(1-propyn-1-yl)-1-piperazinecarboxylate; With chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; sodium t-butanolate; ruphos; In 1,4-dioxane; at 100 ℃; for 1.25h; Inert atmosphere; Sealed tube;

Reference yield:

: 58757-38-3
6-Chloronicotinoyl chloride

: 1450620-42-4
benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyridinyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetramethylammonium fluoride / 1,2-dimethoxyethane / 15 h / -78 - 20 °C

2.1: hydrogen bromide; acetic acid / dichloromethane / 15 h / 20 - 50 °C

2.3: 1.25 h / 100 °C / Inert atmosphere; Sealed tube

With tetramethylammonium fluoride; hydrogen bromide; acetic acid; In 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: 1450620-14-0
4-benzyl 1-tert-butyl 2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate

: 1450620-42-4
benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyridinyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Chiralpak^? ADH column / ethanol / Resolution of racemate

2.1: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

3.1: hydrogen bromide; acetic acid / dichloromethane / 15 h / 20 - 50 °C

3.3: 1.25 h / 100 °C / Inert atmosphere; Sealed tube

With hydrogen bromide; acetic acid; trifluoroacetic acid; In ethanol; dichloromethane;