Succinic anhydride-2,2,3,3-d4

Base Information

• Chemical Name: Succinic anhydride-2,2,3,3-d4
• CAS No.: 14341-86-7
• Molecular Formula: C4D4 O3
• Molecular Weight: 104.042
• European Community (EC) Number: 687-097-9
• DSSTox Substance ID: DTXSID80514615
• Nikkaji Number: J364.616E
• Wikidata: Q82375051
• Mol file: 14341-86-7.mol

Synonyms:14341-86-7;Succinic anhydride-2,2,3,3-d4;Succinic Anhydride-d4;succinic-d4 anhydride;3,3,4,4-tetradeuteriooxolane-2,5-dione;(~2~H_4_)Oxolane-2,5-dione;succinic-d4anhydride;succinic-d4-anhydride;SCHEMBL1333221;DTXSID80514615;HY-79369S;AKOS015912677;CS-0226172;D99449;Succinic anhydride-2,2,3,3-d4, 98 atom % D;J-007813

Chemical Property of Succinic anhydride-2,2,3,3-d4

Chemical Property:

• Vapor Pressure: 0.0118mmHg at 25°C
• Melting Point: 118-120 °C(lit.)
• Refractive Index: 1.47
• Boiling Point: 261 °C
• Flash Point: 122.1°C
• PSA: 43.37000
• Density: 1.43g/cm³
• LogP: -0.15000
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 104.041150969
• Heavy Atom Count: 7
• Complexity: 102

Purity/Quality:

99% ^*data from raw suppliers

Succinic Anhydride-d4 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 36/37-22
• Safety Statements: 25-46

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(=O)OC1=O
• Isomeric SMILES: [2H]C1(C(=O)OC(=O)C1([2H])[2H])[2H]
• Uses: SUCCINIC-D4 ANHYDRIDE is used in the synthesis of propanoyloxy derivatives used as drug absorption modifiers. In addition it is a reagent for novel non-carboxylate inhibitors of AKR1C3 Labelled Succinic Anhydride is used in the synthesis of propanoyloxy derivatives used as drug absorption modifiers. In addition it is a reagent for novel non-carboxylate inhibitors of AKR1C3

Technology Process of Succinic anhydride-2,2,3,3-d4

There total 3 articles about Succinic anhydride-2,2,3,3-d4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-bis(dideuteriomethylene)cyclopentane (77969-58-5) → succinic acid anhydride (108-30-5) + succinic anhydride-2,2,3,3-d4 (14341-86-7) + C4H2(2)H2O3

Guidance literature:

With dihydrogen peroxide; acetic anhydride; ozone; acetic acid; Product distribution; Rate constant; multistep reaction, other reaction time, deuterium distribution in pyrolysis products;

DOI:10.1021/ja00404a028

Reference yield:

2,2,3,3-tetradeuterio-succinic acid (14493-42-6) → succinic anhydride-2,2,3,3-d4 (14341-86-7)

Guidance literature:

With trichlorophosphate;

DOI:10.1021/ja01296a038

Reference yield:

→ succinic anhydride-2,2,3,3-d4 (14341-86-7)

Guidance literature:

aus Bernsteinsaeure-d(4);

upstream raw materials:

2,2,3,3-tetradeuterio-succinic acid

1,3-bis(dideuteriomethylene)cyclopentane

Downstream raw materials:

C₃₉H₄₇⁽²⁾H₄N₇O₁₁S

4-{(S)-2-[4-(4-chloro-phenyloxy)-phenoxymethyl]-pyrrolidin-1-yl}-4-oxo-butyric acid (d4)

Refernces

• 1、 -. "BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION". Page/Page column 48. . Retrieved 2008/06/13.