N-(3,7,7-trimethyl-2-(4-nitrophenyl)-5-oxo-5,6,7,8-tetrahydroquinolin-1(2H)-yl)benzamide

Base Information

• Chemical Name: N-(3,7,7-trimethyl-2-(4-nitrophenyl)-5-oxo-5,6,7,8-tetrahydroquinolin-1(2H)-yl)benzamide
• CAS No.: 1564277-39-9
• Molecular Formula: C₂₅H₂₅N₃O₄
• Molecular Weight: 431.491

Synonyms:N-(3,7,7-trimethyl-2-(4-nitrophenyl)-5-oxo-5,6,7,8-tetrahydroquinolin-1(2H)-yl)benzamide

Chemical Property of N-(3,7,7-trimethyl-2-(4-nitrophenyl)-5-oxo-5,6,7,8-tetrahydroquinolin-1(2H)-yl)benzamide

Chemical Property:

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Technology Process of N-(3,7,7-trimethyl-2-(4-nitrophenyl)-5-oxo-5,6,7,8-tetrahydroquinolin-1(2H)-yl)benzamide

There total 3 articles about N-(3,7,7-trimethyl-2-(4-nitrophenyl)-5-oxo-5,6,7,8-tetrahydroquinolin-1(2H)-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

p-nitro-α-methylcinnamaldehyde (37524-18-8) + N'-(5,5-Dimethyl-3-oxo-1-cyclohexenyl)-benzoesaeurehydrazid → N-(3,7,7-trimethyl-2-(4-nitrophenyl)-5-oxo-5,6,7,8-tetrahydroquinolin-1(2H)-yl)benzamide (1564277-39-9)

Guidance literature:

With ethylenediamine diacetic acid; In N,N-dimethyl-formamide; at 115 ℃; for 0.133333h; Microwave irradiation;

DOI:10.3987/COM-13-12844

Reference yield:

benzoic acid hydrazide (613-94-5) → N-(3,7,7-trimethyl-2-(4-nitrophenyl)-5-oxo-5,6,7,8-tetrahydroquinolin-1(2H)-yl)benzamide (1564277-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / water / 2 h / Reflux

2: ethylenediamine diacetic acid / N,N-dimethyl-formamide / 0.13 h / 115 °C / Microwave irradiation

With acetic acid; ethylenediamine diacetic acid; In water; N,N-dimethyl-formamide; 2: |Knoevenagel Condensation;

DOI:10.3987/COM-13-12844

Reference yield:

dimedone (126-81-8) → N-(3,7,7-trimethyl-2-(4-nitrophenyl)-5-oxo-5,6,7,8-tetrahydroquinolin-1(2H)-yl)benzamide (1564277-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / water / 2 h / Reflux

2: ethylenediamine diacetic acid / N,N-dimethyl-formamide / 0.13 h / 115 °C / Microwave irradiation

With acetic acid; ethylenediamine diacetic acid; In water; N,N-dimethyl-formamide; 2: |Knoevenagel Condensation;

DOI:10.3987/COM-13-12844

upstream raw materials:

p-nitro-α-methylcinnamaldehyde

benzoic acid hydrazide

dimedone

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