N-(2-chlorophenyl)-2-(4-chlorophenyl)-N-methyl-2-oxoacetamide

Base Information

• Chemical Name: N-(2-chlorophenyl)-2-(4-chlorophenyl)-N-methyl-2-oxoacetamide
• CAS No.: 1309455-55-7
• Molecular Formula: C₁₅H₁₁Cl₂NO₂
• Molecular Weight: 308.164
• Mol file: 1309455-55-7.mol

Synonyms:N-(2-chlorophenyl)-2-(4-chlorophenyl)-N-methyl-2-oxoacetamide

Chemical Property of N-(2-chlorophenyl)-2-(4-chlorophenyl)-N-methyl-2-oxoacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-chlorophenyl)-2-(4-chlorophenyl)-N-methyl-2-oxoacetamide

There total 3 articles about N-(2-chlorophenyl)-2-(4-chlorophenyl)-N-methyl-2-oxoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H9Cl2NO2 (1268136-05-5) + methyl iodide (74-88-4) → N-(2-chlorophenyl)-2-(4-chlorophenyl)-N-methyl-2-oxoacetamide (1309455-55-7)

Guidance literature:

C₁₄H₉Cl₂NO₂; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1002/chem.201100256

Reference yield:

4-chlorophenylglyoxylic acid (7099-88-9) → N-(2-chlorophenyl)-2-(4-chlorophenyl)-N-methyl-2-oxoacetamide (1309455-55-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

3.2: 0 - 20 °C

With oxalyl dichloride; sodium hydride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

DOI:10.1002/chem.201100256

Reference yield:

2-(4-chlorophenyl)-2-oxoacetyl chloride (104132-79-8) → N-(2-chlorophenyl)-2-(4-chlorophenyl)-N-methyl-2-oxoacetamide (1309455-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

2.2: 0 - 20 °C

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1002/chem.201100256

upstream raw materials:

C₁₄H₉Cl₂NO₂

methyl iodide

4-chlorophenylglyoxylic acid

2-(4-chlorophenyl)-2-oxoacetyl chloride

Downstream raw materials:

3-(biphenyl-4-yl)-3-hydroxy-1-methylindolin-2-one

3-(4-chlorophenyl)-3-hydroxy-1-methylindolin-2-one