METHYL 4-IODOBUTYRATE

Base Information

• Chemical Name: METHYL 4-IODOBUTYRATE
• CAS No.: 14273-85-9
• Molecular Formula: C5H9 I O2
• Molecular Weight: 228.03
• Hs Code.: 29159000
• Mol file: 14273-85-9.mol

Synonyms:Butyricacid, 4-iodo-, methyl ester (8CI); 4-Iodobutanoic acid methyl ester;4-Iodobutyric acid methyl ester; Methyl 4-iodobutanoate; Methyl 4-iodobutyrate;Methyl g-iodobutyrate

Chemical Property of METHYL 4-IODOBUTYRATE

Chemical Property:

• Vapor Pressure: 0.337mmHg at 25°C
• Refractive Index: n20/D 1.505(lit.)
• Boiling Point: 199.7°Cat760mmHg
• Flash Point: 74.6°C
• PSA: 26.30000
• Density: 1.709g/cm³
• LogP: 1.37460
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl4-Iodobutanoate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 4-iodobutyrate may be used as reagent in the synthesis of 4-[formyl-5-(methoxymethyl)-1H-pyrrol-1-yl] butanoic acid. It has been used in the synthesis of a range of stable S-adenosylmethionine (SAM) mimetics. Their ability to promote the binding of the E. coli methionine repressor (MetJ) to its operator DNA has been investigated.

Technology Process of METHYL 4-IODOBUTYRATE

There total 12 articles about METHYL 4-IODOBUTYRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.5%

methyl 4-chlorobutyrate (3153-37-5) → methyl 4-iodobutanoate (14273-85-9)

Guidance literature:

With sodium iodide; In acetone; for 42h; Heating;

DOI:10.1139/v93-152

Reference yield: 76.0%

Methyl 4-bromobutyrate (4897-84-1) → methyl 4-iodobutanoate (14273-85-9)

Guidance literature:

With sodium iodide; In acetone; for 24h; Reflux;

DOI:10.1021/jacs.7b10519

Reference yield: 41.0%

→ methyl 4-iodobutanoate (14273-85-9)

Guidance literature:

With iodine; In dichloromethane; at -20 ℃; for 10h;

upstream raw materials:

methanol

4-iodobutanoic acid

ω-Diazo-buttersaeuremethylester

4-butanolide

Downstream raw materials:

methyl 4-(N-benzyl-N-(2-methoxycarbonylethyl))aminobutyrate

2-(4-chlorophenyl)-2,5-dihydro-7-(3-methoxycarbonylpropyl)-6-methylpyrazolo[4,3-c]pyridin-3-one

(2S,4S)-2-(1,1-dimethylethyl)-4-(methoxycarbonylbutyl)-5-oxo-3-oxazolidinecarboxylic acid phenylmethyl ester

1-phenylpyrrolidin-2-one

Refernces

• 1、 Lovinger, Gabriel J.,Morken, James P.. "Ni-Catalyzed Enantioselective Conjunctive Coupling with C(sp3) Electrophiles: A Radical-Ionic Mechanistic Dichotomy". . p. 17293 - 17296. Retrieved 2017.
• 2、 Rauser, Marian,Eckert, Raphael,Gerbershagen, Max,Niggemann, Meike. "Catalyst-Free Reductive Coupling of Aromatic and Aliphatic Nitro Compounds with Organohalides". supporting information. p. 6713 - 6717. Retrieved 2019/04/14.