(E)-(3S,7S,8S)-8,9-Bis-benzyloxy-7-benzyloxymethyl-1-[(2S,3S,5R,6S)-3-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-5-methyl-tetrahydro-pyran-2-yl]-3,5-dimethyl-non-5-en-1-one

Base Information

Chemical Name:(E)-(3S,7S,8S)-8,9-Bis-benzyloxy-7-benzyloxymethyl-1-[(2S,3S,5R,6S)-3-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-5-methyl-tetrahydro-pyran-2-yl]-3,5-dimethyl-non-5-en-1-one
CAS No.:123444-72-4
Molecular Formula:C₄₆H₆₆O₇Si
Molecular Weight:759.111
Hs Code.:

(E)-(3S,7S,8S)-8,9-Bis-benzyloxy-7-benzyloxymethyl-1-[(2S,3S,5R,6S)-3-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-5-methyl-tetrahydro-pyran-2-yl]-3,5-dimethyl-non-5-en-1-one

Synonyms:(E)-(3S,7S,8S)-8,9-Bis-benzyloxy-7-benzyloxymethyl-1-[(2S,3S,5R,6S)-3-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-5-methyl-tetrahydro-pyran-2-yl]-3,5-dimethyl-non-5-en-1-one

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Chemical Property of (E)-(3S,7S,8S)-8,9-Bis-benzyloxy-7-benzyloxymethyl-1-[(2S,3S,5R,6S)-3-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-5-methyl-tetrahydro-pyran-2-yl]-3,5-dimethyl-non-5-en-1-one

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Technology Process of (E)-(3S,7S,8S)-8,9-Bis-benzyloxy-7-benzyloxymethyl-1-[(2S,3S,5R,6S)-3-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-5-methyl-tetrahydro-pyran-2-yl]-3,5-dimethyl-non-5-en-1-one

There total 18 articles about (E)-(3S,7S,8S)-8,9-Bis-benzyloxy-7-benzyloxymethyl-1-[(2S,3S,5R,6S)-3-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-5-methyl-tetrahydro-pyran-2-yl]-3,5-dimethyl-non-5-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 123465-13-4
(E)-(3S,7S,8S)-2-Benzenesulfonyl-8,9-bis-benzyloxy-7-benzyloxymethyl-1-[(2S,3S,5R,6S)-3-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-5-methyl-tetrahydro-pyran-2-yl]-3,5-dimethyl-non-5-en-1-one

: 123444-72-4
(E)-(3S,7S,8S)-8,9-Bis-benzyloxy-7-benzyloxymethyl-1-[(2S,3S,5R,6S)-3-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-5-methyl-tetrahydro-pyran-2-yl]-3,5-dimethyl-non-5-en-1-one

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; Heating;
DOI:10.1016/S0040-4039(01)80352-X

Reference yield:

: 35905-41-0
methyl 4,6-O-benzylidene-2,3-dideoxy-2-C-methylene-α-D-erythro-hexopyranoside

: 123444-72-4
(E)-(3S,7S,8S)-8,9-Bis-benzyloxy-7-benzyloxymethyl-1-[(2S,3S,5R,6S)-3-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-5-methyl-tetrahydro-pyran-2-yl]-3,5-dimethyl-non-5-en-1-one

Guidance literature:: Multi-step reaction with 9 steps

1: 67 percent / hydrogen / Pd-C / ethanol

2: 92 percent / hydrogen / Pd(OH)2 / ethanol

3: 84 percent / Ph₃P, DIAD / tetrahydrofuran

4: 89 percent / imidazole / DMAP / dimethylformamide / 70 °C

5: 96 percent / DIBAL-H / CH₂Cl₂ / -78 °C

6: RuCl₃, NaIO₄ / CCl₄; acetonitrile; H₂O

7: K₂CO₃ / dimethylformamide

8: 1.) n-butyllithium / 1.) THF, -78 deg C, 10 min, 2.) 0 deg C, 1 h

9: 84 percent / tri-n-butyltin hydride, AIBN / toluene / Heating

With 1H-imidazole; ruthenium trichloride; sodium periodate; n-butyllithium; 2,2'-azobis(isobutyronitrile); di-isopropyl azodicarboxylate; hydrogen; tri-n-butyl-tin hydride; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; dmap; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0040-4039(01)80352-X

Reference yield:

: 123474-66-8
(2R,3S,5R,6S)-2-Hydroxymethyl-6-methoxy-5-methyl-tetrahydro-pyran-3-ol

: 123444-72-4
(E)-(3S,7S,8S)-8,9-Bis-benzyloxy-7-benzyloxymethyl-1-[(2S,3S,5R,6S)-3-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-5-methyl-tetrahydro-pyran-2-yl]-3,5-dimethyl-non-5-en-1-one

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / Ph₃P, DIAD / tetrahydrofuran

2: 89 percent / imidazole / DMAP / dimethylformamide / 70 °C

3: 96 percent / DIBAL-H / CH₂Cl₂ / -78 °C

4: RuCl₃, NaIO₄ / CCl₄; acetonitrile; H₂O

5: K₂CO₃ / dimethylformamide

6: 1.) n-butyllithium / 1.) THF, -78 deg C, 10 min, 2.) 0 deg C, 1 h

7: 84 percent / tri-n-butyltin hydride, AIBN / toluene / Heating

With 1H-imidazole; ruthenium trichloride; sodium periodate; n-butyllithium; 2,2'-azobis(isobutyronitrile); di-isopropyl azodicarboxylate; tri-n-butyl-tin hydride; diisobutylaluminium hydride; potassium carbonate; triphenylphosphine; dmap; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0040-4039(01)80352-X