1-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone

Base Information

Chemical Name:1-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone
CAS No.:1011533-72-4
Molecular Formula:C₃₁H₃₆N₂O₂Si
Molecular Weight:496.725
Hs Code.:

Synonyms:1-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone

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Chemical Property of 1-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone

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Technology Process of 1-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone

There total 2 articles about 1-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: C₂₉H₃₄N₂OSi

: 75-36-5
acetyl chloride

: 1011533-72-4
1-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone

Guidance literature:: With 2,6-dimethylpyridine; (S,R,R)-N,N-diisobutyl-3,3-dimethyl-2-{3-[2-(2-methyl-5-phenyl-pyrrol-1-yl)-cyclohexyl]-thioureido}-butyramide; In diethyl ether; at -78 - -60 ℃; for 23h; optical yield given as %ee;
DOI:10.1021/ol702781q

Reference yield:

: 75-36-5
acetyl chloride

: [3-(tert-butyl-diphenyl-silanyloxy)-propylidene]-[2-(1H-indol-3-yl)-ethyl]-amine

: 1011533-72-4
1-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone

: (R)-1-{1-[2-(tert-butyldiphenylsilanyloxy)ethyl]-1,3,4,9-tetrahydro-β-carbolin-2-yl}ethanone

Guidance literature:: With 2,6-dimethylpyridine; chiral substituted thioureidobutyramide; In diethyl ether; at -60 ℃; for 22h; Title compound not separated from byproducts;
DOI:10.1021/ja046259p

Reference yield: 74.0%

: 1011533-72-4
1-((S)-3,4-dihydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone

: 1011533-73-5
(S)-2,3,4,9-tetrahydro-1-(2-(tert-butyldiphenylsilanyloxy)ethyl)-1H-pyrido[3,4-b]indole

Guidance literature:: With borane-ammonia complex; lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃; for 30h;
DOI:10.1021/ol702781q