6-chloro-9-(2-deoxy-2-fluoro-3,5-di-O-trityl-β-D-arabinofuranosyl)purine

Base Information

Chemical Name:6-chloro-9-(2-deoxy-2-fluoro-3,5-di-O-trityl-β-D-arabinofuranosyl)purine
CAS No.:144927-25-3
Molecular Formula:C₄₈H₃₈ClFN₄O₃
Molecular Weight:773.306
Hs Code.:

Synonyms:6-chloro-9-(2-deoxy-2-fluoro-3,5-di-O-trityl-β-D-arabinofuranosyl)purine

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Chemical Property of 6-chloro-9-(2-deoxy-2-fluoro-3,5-di-O-trityl-β-D-arabinofuranosyl)purine

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Technology Process of 6-chloro-9-(2-deoxy-2-fluoro-3,5-di-O-trityl-β-D-arabinofuranosyl)purine

There total 4 articles about 6-chloro-9-(2-deoxy-2-fluoro-3,5-di-O-trityl-β-D-arabinofuranosyl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 144925-68-8
9-(3',5'-di-O-trityl-β-D-ribofuranosyl)-6-chloropurine

: 144927-25-3
6-chloro-9-(2-deoxy-2-fluoro-3,5-di-O-trityl-β-D-arabinofuranosyl)purine

Guidance literature:: With pyridine; diethylamino-sulfur trifluoride; In dichloromethane; for 6h; Heating;
DOI:10.1248/cpb.44.2331

Reference yield:

: 2004-06-0
6-Chloropurine riboside

: 144927-25-3
6-chloro-9-(2-deoxy-2-fluoro-3,5-di-O-trityl-β-D-arabinofuranosyl)purine

Guidance literature:: Multi-step reaction with 2 steps

1: 23 percent / DMAP / CH₂Cl₂

2: 87 percent / (diethylamino)sulfur trifluoride; pyridine

With pyridine; dmap; diethylamino-sulfur trifluoride; In dichloromethane;
DOI:10.1081/NCN-120021951

Reference yield:

: 76-83-5
trityl chloride

: 144927-25-3
6-chloro-9-(2-deoxy-2-fluoro-3,5-di-O-trityl-β-D-arabinofuranosyl)purine

Guidance literature:: Multi-step reaction with 2 steps

1: 23 percent / Et₃N, 4-dimethylaminopyridine / CH₂Cl₂ / 16 h / Heating

2: 87 percent / diethylaminosulfur trifluoride (DAST), pyridine / CH₂Cl₂ / 6 h / Heating

With pyridine; dmap; diethylamino-sulfur trifluoride; triethylamine; In dichloromethane;
DOI:10.1248/cpb.44.2331