methyl 4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoate

Base Information

Chemical Name:methyl 4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoate
CAS No.:1360918-36-0
Molecular Formula:C₂₃H₂₁Cl₂F₃N₂O₅
Molecular Weight:533.331
Hs Code.:

Synonyms:methyl 4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoate

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Chemical Property of methyl 4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoate

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Technology Process of methyl 4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoate

There total 6 articles about methyl 4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₀BrCl₂F₃N₂O₅

: 1360918-36-0
methyl 4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoate

Guidance literature:: C₂₃H₂₀BrCl₂F₃N₂O₅; With acetic acid; zinc; at 35 ℃; for 0.166667h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 619-42-1
4-methoxycarbonylphenyl bromide

: 1360918-36-0
methyl 4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / 18 h / Inert atmosphere; Heating

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 55 °C

4: zinc; acetic acid / 0.17 h / 35 °C

With hydrogenchloride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; copper(l) iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 169206-55-7
2-oxo-1-oxa-3,8-diazaspiro<4.5>decane-8-carboxylic acid tert-butyl ester

: 1360918-36-0
methyl 4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / copper(l) iodide; N,N`-dimethylethylenediamine / 18 h / Inert atmosphere; Heating

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 55 °C

4: zinc; acetic acid / 0.17 h / 35 °C

With hydrogenchloride; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; copper(l) iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane; N,N-dimethyl-formamide;