3-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine

Base Information

• Chemical Name: 3-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine
• CAS No.: 939821-44-0
• Molecular Formula: C₁₅H₈F₆N₂
• Molecular Weight: 330.232
• Mol file: 939821-44-0.mol

Synonyms:3-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine

Chemical Property of 3-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine

There total 4 articles about 3-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine (743407-46-7) + Langlois reagent (2926-29-6) → 3-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine (939821-44-0)

Guidance literature:

With anthraquinone-2-carboxylic acid; potassium carbonate; trifluoroacetic acid; In dimethyl sulfoxide; at 20 ℃; for 24h; regioselective reaction; Irradiation; Inert atmosphere;

DOI:10.1016/j.tetlet.2019.02.003

Reference yield: 70.0%

2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine (743407-46-7) + Togni's reagent II (887144-94-7) → 3-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine (939821-44-0)

Guidance literature:

With potassium phosphate; [Cu₄I₄(PPh₃)₄]; In 1,4-dioxane; at 20 ℃; for 6h;

DOI:10.1016/j.tetlet.2019.01.026

Reference yield: 63.0%

2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine (743407-46-7) + (trifluoromethyl)trimethylsilane (81290-20-2) → 3-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine (939821-44-0)

Guidance literature:

With [bis(acetoxy)iodo]benzene; cesium fluoride; In acetonitrile; at 30 ℃; for 3h; Schlenk technique; Sealed tube;

DOI:10.1002/adsc.201801541

upstream raw materials:

2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine

Togni's reagent II

Langlois reagent

(trifluoromethyl)trimethylsilane