2-(4-fluoro-phenyl)4-oxo-4,5-dihydro-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester

Base Information

Chemical Name:2-(4-fluoro-phenyl)4-oxo-4,5-dihydro-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester
CAS No.:868563-97-7
Molecular Formula:C₁₅H₁₁FN₂O₃S
Molecular Weight:318.328
Hs Code.:

Synonyms:2-(4-fluoro-phenyl)4-oxo-4,5-dihydro-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester

Suppliers and Price of 2-(4-fluoro-phenyl)4-oxo-4,5-dihydro-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(4-fluoro-phenyl)4-oxo-4,5-dihydro-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(4-fluoro-phenyl)4-oxo-4,5-dihydro-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester

There total 5 articles about 2-(4-fluoro-phenyl)4-oxo-4,5-dihydro-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 868563-96-6
5-(4-fluorophenyl)-3-thiophenecarboxylic acid ethyl ester

: 95-92-1
oxalic acid diethyl ester

: 868563-97-7
2-(4-fluoro-phenyl)4-oxo-4,5-dihydro-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester

Guidance literature:: 5-(4-fluorophenyl)-3-thiophenecarboxylic acid ethyl ester; oxalic acid diethyl ester; With lithium diisopropyl amide; In tetrahydrofuran; for 0.166667h; Cooling with acetone-dry ice;

With hydrogenchloride; water; at 20 ℃; Cooling with acetone-dry ice;

With hydrazine; In ethanol; water; at 20 - 60 ℃; for 0.666667h;

Reference yield:

: 88-13-1
3-Thiophene carboxylic acid

: 868563-97-7
2-(4-fluoro-phenyl)4-oxo-4,5-dihydro-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; pyridinium hydrobromide perbromide; hydrogen bromide / 24 h / 20 °C

2: sulfuric acid / 24 h / Reflux

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 24 h / Reflux; Inert atmosphere

4: lithium diisopropyl amide / tetrahydrofuran / 1 h / -50 - -40 °C / Inert atmosphere

5: hydrazine hydrate / ethanol / 24 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; pyridinium hydrobromide perbromide; sulfuric acid; hydrogen bromide; sodium carbonate; hydrazine hydrate; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1016/j.bioorg.2022.105704

Reference yield:

: 100523-84-0
2-bromothiophene-4-carboxylic acid

: 868563-97-7
2-(4-fluoro-phenyl)4-oxo-4,5-dihydro-thieno[2,3-d]pyridazine-7-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 24 h / Reflux

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 24 h / Reflux; Inert atmosphere

3: lithium diisopropyl amide / tetrahydrofuran / 1 h / -50 - -40 °C / Inert atmosphere

4: hydrazine hydrate / ethanol / 24 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; sodium carbonate; hydrazine hydrate; lithium diisopropyl amide; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1016/j.bioorg.2022.105704