5-bromothiophene-3-carboxylic acid

Base Information

• Chemical Name: 5-bromothiophene-3-carboxylic acid
• CAS No.: 100523-84-0
• Molecular Formula: C5H3BrO2S
• Molecular Weight: 207.048
• Hs Code.: 2934999090
• Mol file: 100523-84-0.mol

Synonyms:5-bromothiophene-3-carboxylic acid;2-Bromothiophene-4-carboxylicacid;5-Bromo-3-thiophenecarboxylic acid;

Chemical Property of 5-bromothiophene-3-carboxylic acid

Chemical Property:

• Melting Point: 140-144°C
• Boiling Point: 318.907 °C at 760 mmHg
• PKA: 3.82±0.10(Predicted)
• Flash Point: 146.67 °C
• PSA: 65.54000
• Density: 1.924 g/cm³
• LogP: 2.20880
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

5-bromothiophene-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromothiophene-3-carboxylic acid

There total 7 articles about 5-bromothiophene-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-Thiophene carboxylic acid (88-13-1) → 2-bromothiophene-4-carboxylic acid (100523-84-0)

Guidance literature:

With bromine; acetic acid; at 20 ℃;

Reference yield: 92.0%

5-bromo-3-thiophenecarboxylic acid ethyl ester (170355-38-1) → 2-bromothiophene-4-carboxylic acid (100523-84-0)

Guidance literature:

5-bromo-3-thiophenecarboxylic acid ethyl ester; With methanol; sodium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 18h;

With hydrogenchloride; In water; pH=1;

Reference yield:

3-Thiophene carboxylic acid (88-13-1) → 2-bromothiophene-4-carboxylic acid (100523-84-0) + 2,5-dibromothiophene-3-carboxylic acid (7311-70-8)

Guidance literature:

With bromine; acetic acid; for 0.666667h;

upstream raw materials:

n-butyllithium

2,5-dibromothiophene-3-carboxylic acid

diethyl ether

3-Thiophene carboxylic acid

Downstream raw materials:

5-Brom-thiophen-3-carbonsaeureazid

5-Brom-thiophen-⁽³⁾-carbonsaeurechlorid

N,N-dimethyl-N'-[2]pyridyl-N'-[3]thienylmethyl-ethylenediamine

5-bromothiophene-3-carboxylic acid methyl ester

Refernces

• 1、 Zhou, Xiaocheng,Zhang, Zhifang,Hendsbee, Arthur D.,Ngai, Jenner H. L.,Kumar, Pankaj,Ye, Shuyang,Seferos, Dwight S.,Li, Yuning. "-4,4′-dicarboxamide: A novel building block for semiconducting polymers". . p. 30496 - 30502. Retrieved 2019.
• 2、 -. "METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION". Paragraph 0935. . Retrieved 2021/11/20.