methyl {(8R)-8-[[(2R)-2-(4-fluorophenyl)propanoyl](methyl)amino]-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl}acetate

Base Information

Chemical Name:methyl {(8R)-8-[[(2R)-2-(4-fluorophenyl)propanoyl](methyl)amino]-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl}acetate
CAS No.:1219011-17-2
Molecular Formula:C₂₄H₂₆FN₃O₃
Molecular Weight:423.487
Hs Code.:

Synonyms:methyl {(8R)-8-[[(2R)-2-(4-fluorophenyl)propanoyl](methyl)amino]-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl}acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl {(8R)-8-[[(2R)-2-(4-fluorophenyl)propanoyl](methyl)amino]-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl}acetate

Chemical Property:

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Technology Process of methyl {(8R)-8-[[(2R)-2-(4-fluorophenyl)propanoyl](methyl)amino]-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl}acetate

There total 1 articles about methyl {(8R)-8-[[(2R)-2-(4-fluorophenyl)propanoyl](methyl)amino]-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1219011-16-1
methyl [(8R)-8-(methylamino)-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl]acetate

: 150360-26-2
(2R)-2-(4-fluorophenyl)propanoic acid

: 1219011-17-2
methyl {(8R)-8-[[(2R)-2-(4-fluorophenyl)propanoyl](methyl)amino]-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl}acetate

Guidance literature:: With 2,6-dimethylpyridine; N,N-dimethyl-formamide; HATU; at 0 - 20 ℃;

Reference yield:

: 1219011-17-2
methyl {(8R)-8-[[(2R)-2-(4-fluorophenyl)propanoyl](methyl)amino]-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl}acetate

: 1219010-98-6
2-[(8R)-8-[[(2R)-2-(4-fluorophenyl)propanoyl]methylamino]-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl]acetic acid

Guidance literature:: methyl {(8R)-8-[[(2R)-2-(4-fluorophenyl)propanoyl](methyl)amino]-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl}acetate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; methanol; dichloromethane; water; Product distribution / selectivity;