(2S,3R,6S,7R)-6-Benzyloxy-7-benzyloxymethyl-2-[(2R,3R,4R,5S,6S)-4,5-bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-(2-methoxymethoxy-ethyl)-tetrahydro-pyran-2-ylmethyl]-oxepan-3-ol

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Chemical Name:(2S,3R,6S,7R)-6-Benzyloxy-7-benzyloxymethyl-2-[(2R,3R,4R,5S,6S)-4,5-bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-(2-methoxymethoxy-ethyl)-tetrahydro-pyran-2-ylmethyl]-oxepan-3-ol
CAS No.:250226-68-7
Molecular Formula:C₅₁H₇₀O₁₀Si
Molecular Weight:871.196
Hs Code.:

(2S,3R,6S,7R)-6-Benzyloxy-7-benzyloxymethyl-2-[(2R,3R,4R,5S,6S)-4,5-bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-(2-methoxymethoxy-ethyl)-tetrahydro-pyran-2-ylmethyl]-oxepan-3-ol

Synonyms:(2S,3R,6S,7R)-6-Benzyloxy-7-benzyloxymethyl-2-[(2R,3R,4R,5S,6S)-4,5-bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-(2-methoxymethoxy-ethyl)-tetrahydro-pyran-2-ylmethyl]-oxepan-3-ol

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Chemical Property of (2S,3R,6S,7R)-6-Benzyloxy-7-benzyloxymethyl-2-[(2R,3R,4R,5S,6S)-4,5-bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-(2-methoxymethoxy-ethyl)-tetrahydro-pyran-2-ylmethyl]-oxepan-3-ol

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Technology Process of (2S,3R,6S,7R)-6-Benzyloxy-7-benzyloxymethyl-2-[(2R,3R,4R,5S,6S)-4,5-bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-(2-methoxymethoxy-ethyl)-tetrahydro-pyran-2-ylmethyl]-oxepan-3-ol

There total 33 articles about (2S,3R,6S,7R)-6-Benzyloxy-7-benzyloxymethyl-2-[(2R,3R,4R,5S,6S)-4,5-bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-(2-methoxymethoxy-ethyl)-tetrahydro-pyran-2-ylmethyl]-oxepan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 250226-81-4
[(2R,3R,4R,5S,6S)-4,5-Bis-benzyloxy-2-((6S,7R)-6-benzyloxy-7-benzyloxymethyl-4,5,6,7-tetrahydro-oxepin-2-ylmethyl)-6-(2-methoxymethoxy-ethyl)-tetrahydro-pyran-3-yloxy]-tert-butyl-dimethyl-silane

: 250226-68-7
(2S,3R,6S,7R)-6-Benzyloxy-7-benzyloxymethyl-2-[(2R,3R,4R,5S,6S)-4,5-bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-(2-methoxymethoxy-ethyl)-tetrahydro-pyran-2-ylmethyl]-oxepan-3-ol

Guidance literature:: [(2R,3R,4R,5S,6S)-4,5-Bis-benzyloxy-2-((6S,7R)-6-benzyloxy-7-benzyloxymethyl-4,5,6,7-tetrahydro-oxepin-2-ylmethyl)-6-(2-methoxymethoxy-ethyl)-tetrahydro-pyran-3-yloxy]-tert-butyl-dimethyl-silane; With 2,3-Dimethyl-2-butene; borane-THF; In tetrahydrofuran; at -10 - 0 ℃;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/S0040-4020(02)00045-5

Reference yield:

: 441352-40-5
(5S,6R)-5,7-Bis-benzyloxy-6-hydroxy-heptanoic acid

: 250226-68-7
(2S,3R,6S,7R)-6-Benzyloxy-7-benzyloxymethyl-2-[(2R,3R,4R,5S,6S)-4,5-bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-(2-methoxymethoxy-ethyl)-tetrahydro-pyran-2-ylmethyl]-oxepan-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 20 °C

1.2: 64 percent / 4-(dimethylamino)pyridine / tetrahydrofuran; benzene / Heating

2.1: 75 percent / potassium bis(trimethylsilyl)amide; HMPA / tetrahydrofuran; toluene / 1 h / -78 °C

3.1: NaHCO₃ / Pd(PPh₃)4 / H₂O; tetrahydrofuran; dimethylformamide / 20 h / 50 °C

3.2: 243.1 mg / NaOH; aq. H₂O₂ / tetrahydrofuran / 0 - 20 °C

4.1: 2,3-dimethyl-2-butene; BH₃*THF / tetrahydrofuran / -20 - 0 °C

4.2: 73 percent / NaOH; aq. H₂O₂ / tetrahydrofuran / 2 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; 2,3-Dimethyl-2-butene; borane-THF; 2,4,6-trichlorobenzoyl chloride; potassium hexamethylsilazane; sodium hydrogencarbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; 3.1: Suzuki cross-coupling;
DOI:10.1021/ol990885n

Reference yield:

: 351186-81-7
Phosphoric acid (6S,7R)-6-benzyloxy-7-benzyloxymethyl-4,5,6,7-tetrahydro-oxepin-2-yl ester diphenyl ester

: 250226-68-7
(2S,3R,6S,7R)-6-Benzyloxy-7-benzyloxymethyl-2-[(2R,3R,4R,5S,6S)-4,5-bis-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-6-(2-methoxymethoxy-ethyl)-tetrahydro-pyran-2-ylmethyl]-oxepan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaHCO₃ / Pd(PPh₃)4 / H₂O; tetrahydrofuran; dimethylformamide / 20 h / 50 °C

1.2: 243.1 mg / NaOH; aq. H₂O₂ / tetrahydrofuran / 0 - 20 °C

2.1: 2,3-dimethyl-2-butene; BH₃*THF / tetrahydrofuran / -20 - 0 °C

2.2: 73 percent / NaOH; aq. H₂O₂ / tetrahydrofuran / 2 h

With 2,3-Dimethyl-2-butene; borane-THF; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1.1: Suzuki cross-coupling;
DOI:10.1021/ol990885n