Glutaryl-alanyl-alanyl-prolylethylamide

Base Information

Chemical Name:Glutaryl-alanyl-alanyl-prolylethylamide
CAS No.:83808-37-1
Molecular Formula:C₁₈H₃₀N₄O₆
Molecular Weight:398.459
Hs Code.:
DSSTox Substance ID:DTXSID10232693
Wikidata:Q83113780
Mol file:83808-37-1.mol

Synonyms:glutaryl-Ala-Ala-Pro-NH-ET;glutaryl-alanyl-alanyl-prolylethylamide

Suppliers and Price of Glutaryl-alanyl-alanyl-prolylethylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Glutaryl-alanyl-alanyl-prolylethylamide

Chemical Property:

Vapor Pressure:2.01E-23mmHg at 25°C
Boiling Point:731.7°C at 760 mmHg
Flash Point:396.3°C
PSA：155.38000
Density:1.219g/cm³
LogP:1.83660
XLogP3:-2.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:10
Exact Mass:398.21653469
Heavy Atom Count:28
Complexity:609

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1CCCC1C(=O)NC(=O)C(C)NC(=O)C(C)NC(=O)CCCC(=O)O
Isomeric SMILES:CCN1CCC[C@H]1C(=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CCCC(=O)O

Technology Process of Glutaryl-alanyl-alanyl-prolylethylamide

There total 9 articles about Glutaryl-alanyl-alanyl-prolylethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 108-55-4
glutaric anhydride,

: 84914-64-7
alanyl-alanyl proline ethylamide

: 83808-37-1
4-{(S)-1-[(S)-2-((S)-2-Ethylcarbamoyl-pyrrolidin-1-yl)-1-methyl-2-oxo-ethylcarbamoyl]-ethylcarbamoyl}-butyric acid

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

: 55446-83-8
Proline Ethylamide

: 83808-37-1
4-{(S)-1-[(S)-2-((S)-2-Ethylcarbamoyl-pyrrolidin-1-yl)-1-methyl-2-oxo-ethylcarbamoyl]-ethylcarbamoyl}-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: 5.4 g / N,N'-Dicyclohexylcarbodiimide / dimethylformamide; tetrahydrofuran / 1 h / -5 °C / 1) -5 deg C, 1 h, 2) R_.T_., 12 h

2: 36percent HBr / acetic acid

3: 43 percent / N,N'-dicyclohexylcarbodiimide, 36percent HBr / CH₂Cl₂ / 1) 0 deg C, 2 h, 2) R_.T_., 12 h

4: 90 percent / HBr / acetic acid

5: 91 percent / dimethylformamide / 80 °C

With hydrogen bromide; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 55446-81-6
Benzyloxycarbonylproline Ethylamide

: 83808-37-1
4-{(S)-1-[(S)-2-((S)-2-Ethylcarbamoyl-pyrrolidin-1-yl)-1-methyl-2-oxo-ethylcarbamoyl]-ethylcarbamoyl}-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: 5.7 g / 36percent HBr / acetic acid / 1 h

2: 5.4 g / N,N'-Dicyclohexylcarbodiimide / dimethylformamide; tetrahydrofuran / 1 h / -5 °C / 1) -5 deg C, 1 h, 2) R_.T_., 12 h

3: 36percent HBr / acetic acid

4: 43 percent / N,N'-dicyclohexylcarbodiimide, 36percent HBr / CH₂Cl₂ / 1) 0 deg C, 2 h, 2) R_.T_., 12 h

5: 90 percent / HBr / acetic acid

6: 91 percent / dimethylformamide / 80 °C

With hydrogen bromide; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide;