(Z)-2-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)-N-p-tolylacetamide

Base Information

Chemical Name:(Z)-2-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)-N-p-tolylacetamide
CAS No.:1280669-86-4
Molecular Formula:C₁₉H₁₆N₂O₃S₂
Molecular Weight:384.48
Hs Code.:

Synonyms:(Z)-2-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)-N-p-tolylacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-2-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)-N-p-tolylacetamide

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Technology Process of (Z)-2-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)-N-p-tolylacetamide

There total 3 articles about (Z)-2-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)-N-p-tolylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 141-84-4
2-thioxo-4-thiazolidinone

: 17172-57-5
4-<<(p-toluidinocarbonyl)methyl>oxy>benzaldehyde

: 1280669-86-4
(Z)-2-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)-N-p-tolylacetamide

Guidance literature:: With piperidine; acetic acid; In toluene; for 0.5h; diastereospecific reaction; Molecular sieve; Microwave irradiation;
DOI:10.1016/j.ejmech.2010.12.019

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 1280669-86-4
(Z)-2-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)-N-p-tolylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / chloroform / 2 h / 0 - 5 °C

2: potassium carbonate / acetone / 30 - 34 °C

3: piperidine; acetic acid / toluene / 0.5 h / Molecular sieve; Microwave irradiation

With piperidine; potassium carbonate; acetic acid; triethylamine; In chloroform; acetone; toluene; 3: Knoevenagel condensation;
DOI:10.1016/j.ejmech.2010.12.019

Reference yield:

: 16634-82-5
N-(p-tolyl)-2-chloroacetamide

: 1280669-86-4
(Z)-2-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)phenoxy)-N-p-tolylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 30 - 34 °C

2: piperidine; acetic acid / toluene / 0.5 h / Molecular sieve; Microwave irradiation

With piperidine; potassium carbonate; acetic acid; In acetone; toluene; 2: Knoevenagel condensation;
DOI:10.1016/j.ejmech.2010.12.019