Trifluoro-methanesulfonic acid 2-formyl-4-(2-hydroxy-ethyl)-6-methoxy-phenyl ester

Base Information

Chemical Name:Trifluoro-methanesulfonic acid 2-formyl-4-(2-hydroxy-ethyl)-6-methoxy-phenyl ester
CAS No.:155351-74-9
Molecular Formula:C₁₁H₁₁F₃O₆S
Molecular Weight:328.266
Hs Code.:

Synonyms:Trifluoro-methanesulfonic acid 2-formyl-4-(2-hydroxy-ethyl)-6-methoxy-phenyl ester

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Chemical Property of Trifluoro-methanesulfonic acid 2-formyl-4-(2-hydroxy-ethyl)-6-methoxy-phenyl ester

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Technology Process of Trifluoro-methanesulfonic acid 2-formyl-4-(2-hydroxy-ethyl)-6-methoxy-phenyl ester

There total 7 articles about Trifluoro-methanesulfonic acid 2-formyl-4-(2-hydroxy-ethyl)-6-methoxy-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 155351-73-8
2-(1,3-dioxan-2-yl)-6-methoxy-4-<2-(methoxymethoxy)ethyl>phenyl trifluoromethanosulfonate

: 155351-74-9
Trifluoro-methanesulfonic acid 2-formyl-4-(2-hydroxy-ethyl)-6-methoxy-phenyl ester

Guidance literature:: With sulfuric acid; In tetrahydrofuran; at 50 ℃; for 2h;
DOI:10.1021/ja00082a023

Reference yield:

: 5034-74-2
5-bromo-3-methoxysalicylaldehyde

: 155351-74-9
Trifluoro-methanesulfonic acid 2-formyl-4-(2-hydroxy-ethyl)-6-methoxy-phenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 87.8 percent / K₂CO₃ / ethanol / 3 h / Heating

2: 99.7 percent / TsOH*H₂O / benzene / 1 h / Heating

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2.) THF, Et₂O, from -78 deg C to 0 deg C, 2 h

4: 99.5 percent / i-Pr₂NEt / CH₂Cl₂ / 15 h / Ambient temperature

5: 2.08 g / HCO₂NH₄, 10percent Pd/C / methanol / 0.17 h / Ambient temperature

6: 2.59 g / i-Pr₂NEt / CH₂Cl₂ / 0.17 h / -78 °C

7: 8 N aq. H₂SO₄ / tetrahydrofuran / 2 h / 50 °C

With palladium on activated charcoal; n-butyllithium; sulfuric acid; ammonium formate; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; benzene;
DOI:10.1021/ja00082a023

Reference yield:

: 155351-72-7
2-hydroxy-3-methoxy-5-<5-(methoxymethoxy)ethyl>benzaldehyde trimethylene acetal

: 155351-74-9
Trifluoro-methanesulfonic acid 2-formyl-4-(2-hydroxy-ethyl)-6-methoxy-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2.59 g / i-Pr₂NEt / CH₂Cl₂ / 0.17 h / -78 °C

2: 8 N aq. H₂SO₄ / tetrahydrofuran / 2 h / 50 °C

With sulfuric acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00082a023