2-tert-butyl-4-chloro-5-[4-(3-hydroxypropoxy)benzyloxy]-3-(2H)-pyridazinone

Base Information

Chemical Name:2-tert-butyl-4-chloro-5-[4-(3-hydroxypropoxy)benzyloxy]-3-(2H)-pyridazinone
CAS No.:863888-25-9
Molecular Formula:C₁₈H₂₃ClN₂O₄
Molecular Weight:366.845
Hs Code.:

Synonyms:2-tert-butyl-4-chloro-5-[4-(3-hydroxypropoxy)benzyloxy]-3-(2H)-pyridazinone

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Chemical Property of 2-tert-butyl-4-chloro-5-[4-(3-hydroxypropoxy)benzyloxy]-3-(2H)-pyridazinone

Chemical Property:

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Technology Process of 2-tert-butyl-4-chloro-5-[4-(3-hydroxypropoxy)benzyloxy]-3-(2H)-pyridazinone

There total 5 articles about 2-tert-butyl-4-chloro-5-[4-(3-hydroxypropoxy)benzyloxy]-3-(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 863888-24-8
2-tert-butyl-4-chloro-5-(4-(3-(tert-butyl-dimethylsilyloxy)propoxy)benzyloxy)-3-(2H)-pyridazinone

: 863888-25-9
2-tert-butyl-4-chloro-5-[4-(3-hydroxypropoxy)benzyloxy]-3-(2H)-pyridazinone

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm701443n

Reference yield:

: 3981-65-5
4-(3-hydroxypropoxy)-benzoic acid methyl ester

: 863888-25-9
2-tert-butyl-4-chloro-5-[4-(3-hydroxypropoxy)benzyloxy]-3-(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 2 h

2: lithium aluminium tetrahydride / diethyl ether / 2 h / Cooling with ice

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / Cooling with ice

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h

With 1H-imidazole; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;

Reference yield:

: 863888-22-6
4-[3-(tert-butyldimethylsilanyloxy)propoxy]benzoic acid methyl ester

: 863888-25-9
2-tert-butyl-4-chloro-5-[4-(3-hydroxypropoxy)benzyloxy]-3-(2H)-pyridazinone

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / diethyl ether / 2 h / Cooling with ice

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / Cooling with ice

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; diethyl ether;