4-Amino-2-{[2-({6-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazin-8-yl}amino)ethyl]amino}-1,3-thiazole-5-carbonitrile trifluoroacetate

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Chemical Name:4-Amino-2-{[2-({6-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazin-8-yl}amino)ethyl]amino}-1,3-thiazole-5-carbonitrile trifluoroacetate
CAS No.:1101322-52-4
Molecular Formula:C₂HF₃O₂*C₁₉H₁₅F₃N₈S
Molecular Weight:558.467
Hs Code.:

Synonyms:4-Amino-2-{[2-({6-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazin-8-yl}amino)ethyl]amino}-1,3-thiazole-5-carbonitrile trifluoroacetate

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Chemical Property of 4-Amino-2-{[2-({6-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazin-8-yl}amino)ethyl]amino}-1,3-thiazole-5-carbonitrile trifluoroacetate

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Technology Process of 4-Amino-2-{[2-({6-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazin-8-yl}amino)ethyl]amino}-1,3-thiazole-5-carbonitrile trifluoroacetate

There total 2 articles about 4-Amino-2-{[2-({6-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazin-8-yl}amino)ethyl]amino}-1,3-thiazole-5-carbonitrile trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1101323-80-1
4-amino-2-({2-[(6-bromoimidazo[1,2-a]pyrazin-8-yl)amino]ethyl}amino)-1,3-thiazole-5-carbonitrile

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1101322-52-4
4-Amino-2-{[2-({6-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazin-8-yl}amino)ethyl]amino}-1,3-thiazole-5-carbonitrile trifluoroacetate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 120 ℃; for 15h; Inert atmosphere;

Reference yield:

: 63744-22-9
6,8-dibromoimidazo[1,2-a]pyrazine

: 1101322-52-4
4-Amino-2-{[2-({6-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazin-8-yl}amino)ethyl]amino}-1,3-thiazole-5-carbonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dimethyl sulfoxide / 1 h / 140 °C / Microwave

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 15 h / 120 °C / Inert atmosphere

With sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dimethyl sulfoxide;