diethyl (acetylamino)<<3-<2-(diethoxyphosphinyl)ethyl>phenyl>methyl>propanedioate

Base Information

Chemical Name:diethyl (acetylamino)<<3-<2-(diethoxyphosphinyl)ethyl>phenyl>methyl>propanedioate
CAS No.:120667-50-7
Molecular Formula:C₂₂H₃₄NO₈P
Molecular Weight:471.488
Hs Code.:

Synonyms:diethyl (acetylamino)<<3-<2-(diethoxyphosphinyl)ethyl>phenyl>methyl>propanedioate

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Chemical Property of diethyl (acetylamino)<<3-<2-(diethoxyphosphinyl)ethyl>phenyl>methyl>propanedioate

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Technology Process of diethyl (acetylamino)<<3-<2-(diethoxyphosphinyl)ethyl>phenyl>methyl>propanedioate

There total 4 articles about diethyl (acetylamino)<<3-<2-(diethoxyphosphinyl)ethyl>phenyl>methyl>propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 120667-48-3
diethyl (acetylamino)<<3-<2-(diethoxyphosphinyl)ethenyl>phenyl>methyl>propanedioate

: 120667-50-7
diethyl (acetylamino)<<3-<2-(diethoxyphosphinyl)ethyl>phenyl>methyl>propanedioate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; under 2585.7 Torr;
DOI:10.1021/jm00127a030

Reference yield:

: 823-78-9
meta-bromobenzyl bromide

: 120667-50-7
diethyl (acetylamino)<<3-<2-(diethoxyphosphinyl)ethyl>phenyl>methyl>propanedioate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaOEt / 1.) EtOH, 15 min, 2.) THF, RT, overnight

2: 31 percent / palladium(II)acetate, tri-o-tolylphosphine, tri-n-butylamine / xylene / 1.) 110 deg C, 2 h, 2.) 120 deg C, 1 h, 3.) 135 deg C, 3 h

3: 43 percent / H₂ / Pd/C (5percent) / ethanol / 2585.7 Torr

With tributyl-amine; hydrogen; sodium ethanolate; palladium diacetate; tris-(o-tolyl)phosphine; palladium on activated charcoal; In ethanol; xylene;
DOI:10.1021/jm00127a030

Reference yield:

: 15017-44-4
diethyl (acetylamino)<(3-bromophenyl)methyl>propanedioate

: 120667-50-7
diethyl (acetylamino)<<3-<2-(diethoxyphosphinyl)ethyl>phenyl>methyl>propanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: 31 percent / palladium(II)acetate, tri-o-tolylphosphine, tri-n-butylamine / xylene / 1.) 110 deg C, 2 h, 2.) 120 deg C, 1 h, 3.) 135 deg C, 3 h

2: 43 percent / H₂ / Pd/C (5percent) / ethanol / 2585.7 Torr

With tributyl-amine; hydrogen; palladium diacetate; tris-(o-tolyl)phosphine; palladium on activated charcoal; In ethanol; xylene;
DOI:10.1021/jm00127a030