4-(3'-nitrophenyl)-5-trifluoromethylsulfonyloxyquinazoline

Base Information

Chemical Name:4-(3'-nitrophenyl)-5-trifluoromethylsulfonyloxyquinazoline
CAS No.:733017-08-8
Molecular Formula:C₁₅H₈F₃N₃O₅S
Molecular Weight:399.307
Hs Code.:

Synonyms:4-(3'-nitrophenyl)-5-trifluoromethylsulfonyloxyquinazoline

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Chemical Property of 4-(3'-nitrophenyl)-5-trifluoromethylsulfonyloxyquinazoline

Chemical Property:

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Technology Process of 4-(3'-nitrophenyl)-5-trifluoromethylsulfonyloxyquinazoline

There total 5 articles about 4-(3'-nitrophenyl)-5-trifluoromethylsulfonyloxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 733017-05-5
5-hydroxy-4-(3'-nitrophenyl)quinazoline

: 733017-08-8
4-(3'-nitrophenyl)-5-trifluoromethylsulfonyloxyquinazoline

Guidance literature:: With triethylamine; In dichloromethane; for 15h; Heating;
DOI:10.1016/j.tet.2004.04.065

Reference yield:

: 135106-52-4
5-methoxy-4-(3H)-quinazolinone

: 733017-08-8
4-(3'-nitrophenyl)-5-trifluoromethylsulfonyloxyquinazoline

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / PCl₅; POCl₃ / 15 h / Heating

2: 62 percent / Pd(PPh₃)4; aq. potassium carbonate / toluene / 62 h / Heating

3: 73 percent / pyridinium chloride / 1.5 h / 210 °C

4: 25 percent / Et₃N / CH₂Cl₂ / 15 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus pentachloride; pyridine hydrochloride; potassium carbonate; triethylamine; trichlorophosphate; In dichloromethane; toluene; 2: Suzuki cross-coupling;
DOI:10.1016/j.tet.2004.04.065

Reference yield:

: 54166-96-0
methyl 2-amino-6-methoxybenzoate

: 733017-08-8
4-(3'-nitrophenyl)-5-trifluoromethylsulfonyloxyquinazoline

Guidance literature:: Multi-step reaction with 5 steps

1: CH₃CO₂H / 180 °C

2: 66 percent / PCl₅; POCl₃ / 15 h / Heating

3: 62 percent / Pd(PPh₃)4; aq. potassium carbonate / toluene / 62 h / Heating

4: 73 percent / pyridinium chloride / 1.5 h / 210 °C

5: 25 percent / Et₃N / CH₂Cl₂ / 15 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus pentachloride; pyridine hydrochloride; potassium carbonate; acetic acid; triethylamine; trichlorophosphate; In dichloromethane; toluene; 3: Suzuki cross-coupling;
DOI:10.1016/j.tet.2004.04.065